In vitro effects of phthalate esters in human myometrial and leiomyoma cells and increased urinary level of phthalate metabolite in women with uterine leiomyoma
The present study showed in vitro effects of phthalate in human myometrial and leiomyoma cells and also found that the urinary level of phthalate metabolite is increased in women with leiomyoma.
Volume 107, Issue 4, Pages 1061–1069.e1
Jin Hee Kim, Ph.D., Sung Hoon Kim, M.D., Ph.D., Young Sang Oh, M.S., Hyo Jin Ihm, M.S., Hee Dong Chae, M.D., Ph.D., Chung-Hoon Kim, M.D., Ph.D., Byung Moon Kang, M.D., Ph.D.
These findings suggest that exposure to phthalate may play a role in the pathogenesis of uterine leiomyoma by enhancing proliferative activity, exerting an antiapoptotic effect, and increasing collagen contents in myometrial and leiomyoma cells.