Progesterone luteal support after ovulation induction and intrauterine insemination: an updated systematic review and meta-analysis

Luteal phase support with exogenous P after ovulation induction and IUI was associated with increased clinical pregnancy and live birth rates in gonadotropin cycles.

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Volume 107, Issue 4, Pages 924–933.e5


Katherine A. Green, M.D, Jessica R. Zolton, D.O., Sophia M.V. Schermerhorn, B.S., Terrence D. Lewis, M.D., Ph.D., Mae W. Healy, D.O., Nancy Terry, M.L.S., Alan H. DeCherney, M.D., Micah J. Hill, D.O.


Progesterone luteal phase support is beneficial to patients undergoing ovulation induction with gonadotropins in IUI cycles. The number needed to treat is 11 patients to have one additional live birth. Progesterone support did not benefit patients undergoing ovulation induction with clomiphene citrate or clomiphene plus gonadotropins.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.