Important role of collective cell migration and nerve fiber density in the development of deep nodular endometriosis
Deep endometriotic lesions induced in a baboon model were significantly more invasive and innervated after 1 year rather than after 6 months.
Volume 107, Issue 4, Pages 987–995.e5
Renan Orellana, Ph.D., Javier García-Solares, M.Sc., Jacques Donnez, M.D., Ph.D., Olivier van Kerk, B.Sc., Marie-Madeleine Dolmans, M.D., Ph.D., Olivier Donnez, M.D., Ph.D.
Nodular endometriotic lesions induced in the baboon model were found to be significantly more invasive and innervated after 12 months than after 6 months. The invasive phenotype was highly expressed in glands at the invasion front, and our study suggests that nerve fibers play a role in the development of lesions as observed in women.