Important role of collective cell migration and nerve fiber density in the development of deep nodular endometriosis

Deep endometriotic lesions induced in a baboon model were significantly more invasive and innervated after 1 year rather than after 6 months.

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Volume 107, Issue 4, Pages 987–995.e5


Renan Orellana, Ph.D., Javier García-Solares, M.Sc., Jacques Donnez, M.D., Ph.D., Olivier van Kerk, B.Sc., Marie-Madeleine Dolmans, M.D., Ph.D., Olivier Donnez, M.D., Ph.D.


Nodular endometriotic lesions induced in the baboon model were found to be significantly more invasive and innervated after 12 months than after 6 months. The invasive phenotype was highly expressed in glands at the invasion front, and our study suggests that nerve fibers play a role in the development of lesions as observed in women.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.