Important role of collective cell migration and nerve fiber density in the development of deep nodular endometriosis

Deep endometriotic lesions induced in a baboon model were significantly more invasive and innervated after 1 year rather than after 6 months.

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Volume 107, Issue 4, Pages 987–995.e5


Renan Orellana, Ph.D., Javier García-Solares, M.Sc., Jacques Donnez, M.D., Ph.D., Olivier van Kerk, B.Sc., Marie-Madeleine Dolmans, M.D., Ph.D., Olivier Donnez, M.D., Ph.D.


Nodular endometriotic lesions induced in the baboon model were found to be significantly more invasive and innervated after 12 months than after 6 months. The invasive phenotype was highly expressed in glands at the invasion front, and our study suggests that nerve fibers play a role in the development of lesions as observed in women.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.