Long-term medical management of endometriosis with dienogest and with a gonadotropin-releasing hormone agonist and add-back hormone therapy
Dienogest and gonadotropin-releasing hormone agonist with hormone add-back therapy seem to be equally effective for long-term treatment of pain symptoms associated with endometriosis.
Volume 107, Issue 3, Pages 537–548
Mohamed A. Bedaiwy, M.D., Ph.D., Catherine Allaire, M.D., Sukinah Alfaraj, M.D.
Endometriosis can recur after either surgical or medical therapy. Long-term medical therapy is implemented to treat symptoms or prevent recurrence. Dienogest and gonadotropin-releasing hormone (GnRH) analogues with hormone add-back therapy seem to be equally effective for long-term treatment of pain symptoms associated with endometriosis. There is insufficient evidence to support the superiority of one therapy over the other. However, add-back hormone therapy (HT) is recommended for patients using GnRH agonists. The treatment selection depends on therapeutic effectiveness, tolerability, drug cost, the physician's experience, and expected patient compliance.