New developments in the medical treatment of endometriosis

Emerging medical treatments (gonadotropin-releasing hormone antagonists, selective receptor modulators, aromatase inhibitors, immunomodulators, and antiangiogenic drugs targeting different pathways) will be important for precision health (personalized medicine) in endometriosis.

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Volume 107, Issue 3, Pages 555–565


Mohamed A. Bedaiwy, M.D., Ph.D., Sukinah Alfaraj, M.D., Paul Yong, M.D., Ph.D., Robert Casper, M.D.


Endometriosis affects 1 in 10 women of reproductive-age. The current treatments are surgical and hormonal but have limitations, including the risk of recurrence, side effects, contraceptive action for women who desire pregnancy, and cost. New treatments include gonadotropin-releasing hormone analogues, selective progesterone (or estrogen) receptor modulators, aromatase inhibitors, immunomodulators, and antiangiogenic agents. Further research is needed into central sensitization, local neurogenesis, and the genetics of endometriosis to identify additional treatment targets. A wider range of medical options allows for the possibility of precision health and a more personalized treatment approach for women with endometriosis.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.