Age-related alterations in the genetics and genomics of the male germ line

We review the genetic and genomic abnormalities that develop in the germ line owing to increasing paternal age.

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Volume 107, Issue 2, Pages 319-323


Amin S. Herati, M.D., Boryana H. Zhelyazkova, B.A., Peter R. Butler, B.A., Dolores J. Lamb, Ph.D.


Paternal aging is associated with increased risk of genetic disease transmission to the offspring. The changes associated with aging arise predominantly through formation of single nucleotide variation through DNA replication errors, as well as possibly chronic exposure to environmental toxins and reactive oxygen species exposure. Several age-related reproductive factors are also contributory, including the systemic hormonal milieu, accumulation of environmental toxin exposure, aging germ cells, and accumulation of de novo genetic and genomic abnormalities in germ cells. In this article we review the age-related genetic and genomic changes that occur in the male germ line.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility┬« is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.