Low body mass index compromises live birth rate in fresh transfer in vitro fertilization cycles: a retrospective study in a Chinese population

Among women undergoing fresh transfer cycles, underweight was associated with reduced odds of live birth.

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Volume 107, Issue 2, Pages 422–429

Authors:

Jiali Cai, Ph.D., Lanlan Liu, Ph.D., Junwen Zhang, M.D., Huiling Qiu, Ph.D., Xiaoming Jiang, M.D., Ping Li, M.D., Aiguo Sha, M.D., Jianzhi Ren, M.D.

Abstract:

Objective

To evaluate the effects of low body mass index (BMI) on in vitro fertilization (IVF) outcomes in fresh transfer cycles.

Design

Retrospective cohort study.

Setting

University-affiliated hospital.

Patient(s)

A total of 4,798 cycles with conventional stimulation and fresh transfer in a single IVF center during the period 2013–2014. Low BMI (<18.5 kg/m2) was defined according to World Health Organization guidelines, and cycles within a normal weight range (18.5–24.9 kg/m2) were used as reference.

Intervention(s)

None.

Main Outcome Measure(s)

Live birth rate per fresh embryo transfer.

Result(s)

Low BMI was associated with reduced live birth rates and increased miscarriage rates compared with normal weight, controlling for important covariates known to influence IVF outcomes. Patient age was the most potent confounder, causing a 10.5% reduction in the odds ratio (OR) for live birth between the groups compared. When an interaction term (age × BMI) was introduced, the OR for live birth was reduced in cycles of those aged ≥35 years compared with cycles of those aged 28–34 years, whereas the change in OR between cycles in those aged <28 and cycles in those aged 28–34 years was insignificant.

Conclusion(s)

Low BMI is associated with negative outcomes in fresh transfer cycles, especially for women of advanced age.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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