Is elective single-embryo transfer a viable treatment policy in in vitro maturation cycles?

Elective single-embryo transfer after in vitro maturation seems a viable option for women with polycystic ovary syndrome, younger than 35 years, and undergoing their first two assisted reproduction cycles.

Volume 106, Issue 7, Pages 1691-1695


Safak Hatırnaz, M.D., Ebru Hatırnaz, M.D., Michael H. Dahan, M.D., Seang Lin Tan, M.D., M.B.A., Alev Ozer, M.D., Mine Kanat-Pektas, M.D., Baris Ata, M.D., M.C.T.



To compare the clinical outcome of single-embryo transfer (SET) with double-embryo transfer (DET) in in vitro maturation (IVM) cycles performed in patients with polycystic ovary syndrome (PCOS), and to determine which factors predict those outcomes.


A retrospective analysis.


Private assisted reproduction center.


One hundred and fifty-nine women with PCOS.


In vitro maturation with elective SET or DET conducted between September 2007 and May 2014.

Main Outcome Measure(s)

Live-birth rates.


Single-embryo transfer was performed in 83 patients (52.2%), and DET was performed in 76 patients (47.7%). When compared with the patients who had DET, the patients who had SET were statistically significantly younger (32.4 ± 3.5 vs. 24.1 ± 4.2 years) and had a shorter infertility duration (9.2 ± 4.5 vs. 4.4 ± 2.1 years), fewer previous ART cycles (<2 prior attempts, 39.5% vs. 6%; ≥2 prior attempts, 60.5% vs. 0), fewer collected oocytes (15.1 ± 4.6 vs. 12.6 ± 3.8), fewer metaphase II oocytes (9.0 ± 4.1 vs. 5.7 ± 2.9), fewer fertilized oocytes (8.2 ± 3.7 vs. 3.6 ± 2.3), and a higher implantation rate (27% vs. 47%). The SET and DET groups had similar embryo quality and similar clinical pregnancy (44.6% vs. 44.7%) and live-birth rates (34.9% vs. 34.2%). Twin pregnancy rates were statistically significantly higher in the DET compared with the SET groups (9.2% vs. 2.4%).


In vitro maturation is a successful assisted reproduction technique that can be an alternative to conventional in vitro fertilization in women presenting with PCOS-related infertility. Our observations suggest that SET is a feasible option to prevent multiple pregnancies while maintaining the live-birth rate.

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