Relationship between polycystic ovary syndrome and ancestry in European Americans

Polycystic ovary syndrome (PCOS) status and phenotypic features were examined as a function of genetic background by means of principal component analysis. The data demonstrate genetic influence for PCOS based on European ethnicity.

Like Comment

Volume 106, Issue 7, Pages 1772-1777

Authors:

Andrew C. Bjonnes, M.S., Richa Saxena, Ph.D., Corrine K. Welt, M.D.

Abstract:

Objective

To determine whether European Americans with polycystic ovary syndrome (PCOS) exhibit genetic differences associated with PCOS status and phenotypic features.

Design

Case-control association study in European Americans.

Setting

Academic center.

Subject(s)

Women with PCOS diagnosed with the use of the National Institutes of Health criteria (n = 532) and control women with regular menstrual cycles and no evidence of hyperandrogenism (n = 432).

Intervention(s)

Blood was drawn for measurement of sex steroids, metabolic parameters, and genotyping.

Main Outcome Measure(s)

Associations among PCOS status, phenotype, and genetic background identified with the use of principal component analysis.

Result(s)

Principal component analysis identified five principal components (PCs). PC1 captured northwest-to-southeast European genetic variation and was associated with PCOS status. Acanthosis was associated with southern European ancestry, and larger waist:hip ratio was associated with northern European ancestry. PC2 was associated with east-to-west European genetic variation and cholesterol levels.

Conclusion(s)

These data provide evidence for genetic influence based on European ethnicity in women with PCOS. There is also evidence for a genetic component in the phenotypic features of PCOS within a mixed European population. The data point to the need to control for population stratification in genetic studies in women of mixed European ethnicity. They also emphasize the need for better studies of PCOS prevalence and phenotype as a function of genetic background.


Read the full text here.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.