Associations of parity and age at first pregnancy with overall and cause-specific mortality in the Cancer Prevention Study II

Although associations of parity and age at first birth with overall mortality were small, women who had 6 births, compared with 2, had a 26% higher risk of diabetes mortality.
Associations of parity and age at first pregnancy with overall and cause-specific mortality in the Cancer Prevention Study II

Volume 107, Issue 1, Pages 179-188

Authors:

Mia M. Gaudet, Ph.D., Brian D. Carter, M.P.H., Janet S. Hildebrand, M.P.H., Alpa V. Patel, Ph.D., Peter T. Campbell, Ph.D., Ying Wang, Ph.D., Susan M. Gapstur, Ph.D.

Abstract:

Objective

To evaluate the association of parity, number of live births, and age at first birth with mortality using multivariable-adjusted Cox proportional hazards regression models.

Design

Observational cohort.

Setting

Not applicable.

Patient(s)

A total of 424,797 women.

Intervention(s)

None.

Main Outcome Measure(s)

All-cause and cause-specific mortality.

Result(s)

During median follow-up of 24.93 years, 238,324 deaths occurred. Parous, compared with nulliparous, women had lower rates of all-cause (hazards ratio [HR] = 0.94, 95% confidence interval [CI] 0.93–0.96) mortality, driven by heart disease and overall cancer mortality. A linear trend was found for more births and diabetes mortality (P<.001) with having ≥6 births, compared with 2, associated with an HR of 1.28 (95% CI 1.15–1.43). Compared with age at first birth from 20–22 years, age at first birth <20 years was associated with higher mortality rates overall (HR = 1.04, 95% CI 1.02–1.06), driven by heart disease and chronic obstructive pulmonary disease mortality; whereas, ≥35 years was associated with higher overall cancer mortality (HR = 1.13, 95% CI 1.06–1.20).

Conclusion(s)

Although parity was associated with a slight reduction in rates of all-cause mortality resulting in a minimal impact on average lifespan, the higher diabetes mortality in grand multiparous women might warrant continuous monitoring, particularly for abnormal glucose metabolism, among these women.


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