Increased odds of live birth in fresh in vitro fertilization cycles with shorter ovarian stimulation
Ovarian stimulation 13 days is associated with increased odds of clinical pregnancy and live birth in patients undergoing their first IVF cycle with fresh day 3 ET.
Volume 107, Issue 1, Pages 104-109
Nigel Pereira, M.D., Caroline Friedman, M.D., Anne P. Hutchinson, M.D., Jovana P. Lekovich, M.D., Rony T. Elias, M.D., Zev Rosenwaks, M.D.
To investigate the impact of prolonged ovarian stimulation on pregnancy outcomes in IVF cycles with fresh day 3 ET.
Retrospective cohort study.
All patients initiating their first IVF cycle with fresh day 3 ET. Prolonged ovarian stimulation was defined as a duration of more than two standard deviations (95th percentile) for the study cohort (i.e., >13 days).
Main Outcome Measure(s)
Live birth rate was considered the primary outcome and was compared between patients undergoing ovarian stimulation for ≤13 days and >13 days. Odds ratios (OR) with 95% confidence intervals (CI) for all pregnancy outcomes after day 3 ET were calculated. The OR for live birth was adjusted using logistic regression.
A total of 6,410 and 339 patients underwent ovarian stimulation for ≤13 days and >13 days, respectively. There were no differences in the demographics or mean number of day 3 embryos transferred between the two groups. Ovarian stimulation ≤13 days was associated with increased odds of clinical pregnancy (OR 2.15, 95% CI 1.19–3.89) and live birth (OR 2.35, 95% CI 1.25–4.43). The increased odds for live birth in the ≤13-day group remained unchanged after logistic regression. Patients with clinical pregnancies in the >13-day group were younger (34.6 ± 4.91 years) compared with those who did not conceive (38.2 ± 4.72 years).
Our findings suggest that ovarian stimulation ≤13 days is associated with increased odds of clinical pregnancy and live birth. In patients undergoing ovarian stimulation >13 days, younger age is associated with live birth.