Type of chromosome abnormality affects embryo morphology dynamics

A retrospective study demonstrates differences in the cleavage time between types of embryo chromosomal abnormalities and elaborates on algorithm likelihood to exclude aneuploid embryos.

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Volume 107, Issue 1, Pages 229-235


Maria Del Carmen Nogales, Ph.D., Fernando Bronet, Ph.D., Natalia Basile, Ph.D., Eva María Martínez, Ph.D., Alberto Liñán, Ph.D., Lorena Rodrigo, Ph.D., Marcos Meseguer, Ph.D.



To study the differences in the cleavage time between types of embryo chromosomal abnormalities and elaborate algorithm to exclude aneuploid embryos according to the likelihood to be euploid.


Retrospective cohort study.


University affiliated private center.


Preimplantational genetic screening patients (n = 112) including cases of advanced maternal age, repeated implantation failure, and recurrent miscarriage. A total of 485 embryos were analyzed.



Main Outcome Measure(s)

All biopsied embryos were cultured in an incubator with time-lapse technology, cleavage timing from insemination to day 3 and all kinetic parameters that have been described in previous studies by our group.


Logistic regression analysis were used to identify morphokinetic parameters and some were strongly associated with complex aneuploid embryos; t3 (odds ratio = 0.590, 95% confidence interval 0.359–0.971) and t5–t2 (odds ratio = 0.151, 95% confidence interval 0.082–0.278).


Embryo morphokinetics are affected by chromosome aneuploidy and further analysis of the chromosome content reveals higher differences when the complexity in the chromosome disorders is increased. The use of time-lapse monitoring, although not able to detect an abnormal embryo, may be potentially useful to discard those embryos with high risk of complex chromosomal abnormalities.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.