Volume 106, Issue 7, Pages 1673-1682
Aukje M. Meijerink, M.D., Liliana Ramos, Ph.D., Anjo J.W.M. Janssen, Ph.D., Nienke M. Maas–van Schaaijk, Ph.D., Andreas Meissner, M.D., Sjoerd Repping, M.D., Ph.D., Monique H. Mochtar, M.D., Ph.D., Didi D.M. Braat, M.D., Ph.D., Kathrin Fleischer, M.D., Ph.D.
To evaluate at the age of 5 years the behavioral, cognitive, and motor performance and physical development of children born after testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI).
A prospective longitudinal cohort study.
Two university medical centers.
A total of 103 5-year-olds who were born after TESE-ICSI.
The follow-up of the children was performed by questionnaires at birth and again at 1 year and at 4 years of age. Five-year-old children were invited for individual assessment. Behavioral performance was assessed with the use of the Child Behavior Checklist for parents and teachers. Cognitive performance was assessed with the use of the Dutch Wechsler Preschool and Primary Scale of Intelligence test, 3rd version. Motor performance was assessed with the use of the Dutch Movement Assessment Battery for Children, 2nd version. Physical development was assessed by means of physical examination and medical history.
Main Outcome Measure(s)
Behavioral, cognitive, and motor performance and physical development.
Eighty-nine children were completely assessed, and 14 were partially assessed at the age of 5 years. The 5-year-old cohort assessed significantly better on behavioral and cognitive performance and significantly worse on motor performance—but still in the normal range—compared with the theoretic distribution in the general population. Four children (3.8%) of the 5-year-old cohort had developmental problems/delays. Two of them were previously diagnosed with a form of autism (pervasive developmental disorder—not otherwise specified). Two children had developmental problems based on our behavioral, cognitive, and/or motor assessments.
The long-term effects on development and health in children born after TESE-ICSI procedures seem to be reassuring.