Fertility treatment and childhood type 1 diabetes mellitus: a nationwide cohort study of 565,116 live births

Fertility treatment was not associated with childhood type 1 diabetes mellitus. Ovulation induction or intrauterine insemination with follicle-stimulating hormone may be associated with childhood type 1 diabetes mellitus.

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Volume 106, Issue 7, Pages 1751-1756

Authors:

Laura Ozer Kettner, M.D., Niels Bjerregaard Matthiesen, Ph.D., Cecilia Høst Ramlau-Hansen, Ph.D., Ulrik Schiøler Kesmodel, Ph.D., Bjørn Bay, Ph.D., Tine Brink Henriksen, Ph.D.

Abstract:

Objective

To investigate the association between specific types of fertility treatment and childhood type 1 diabetes mellitus.

Design

Nationwide birth cohort study.

Setting

Not applicable.

Patient(s)

All pregnancies resulting in a live-born singleton child in Denmark from 1995 to 2003.

Intervention(s)

Not applicable.

Main Outcome Measure(s)

Childhood type 1 diabetes mellitus identified from redeemed prescriptions for insulin until 2013.

Result(s)

The study included 565,116 singleton pregnancies. A total of 14,985 children were conceived by ovulation induction or intrauterine insemination, and 8,490 children were conceived by in vitro fertilization or intracytoplasmic sperm injection. During the follow-up period, 2,011 (0.4%) children developed type 1 diabetes mellitus. The primary analyses showed no association between fertility treatment and childhood type 1 diabetes mellitus. In secondary analyses, ovulation induction or intrauterine insemination with follicle-stimulating hormone was associated with an increased risk of type 1 diabetes mellitus (hazard ratio 3.22; 95% confidence interval 1.20 to 8.64). No clear associations were seen with other types of fertility treatment or with specific treatment indications.

Conclusion(s)

No association between fertility treatment and childhood type 1 diabetes mellitus was found. Ovulation induction or intrauterine insemination with follicle-stimulating hormone may be associated with an increased risk of childhood type 1 diabetes mellitus. However, this finding may be due to chance or to confounding by indication and thus requires further investigation.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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