Development of ovarian cancer after excision of endometrioma

Ovarian cancers can develop after the excision of endometrioma and are more likely to arise from recurrent endometrioma.

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Volume 106, Issue 6, Pages 1432-1437


Hirofumi Haraguchi, M.D., Kaori Koga, M.D., Ph.D., Masashi Takamura, M.D., Ph.D., Tomoko Makabe, M.D., Fusako Sue, M.D., Mariko Miyashita, M.D., Yoko Urata, M.D., Ph.D., Gentaro Izumi, M.D., Ph.D., Miyuki Harada, M.D., Ph.D., Tetsuya Hirata, M.D., Ph.D., Yasushi Hirota, M.D., Ph.D., Osamu Wada-Hiraike, M.D., Ph.D., Katsutoshi Oda, M.D., Ph.D., Kei Kawana, M.D., Ph.D., Tomoyuki Fujii, M.D., Ph.D., Yutaka Osuga, M.D., Ph.D.



To determine the prevalence rate of subsequent development of ovarian cancer after excision of endometrioma.


Retrospective cross-sectional study.


University hospital.


A total of 485 women with endometrioma.


Excisions of endometrioma were performed between 1995 and 2004. Data were collected from medical records in 2013.

Main Outcome Measure(s)

Age, revised American Society for Reproductive Medicine score, cyst diameter, follow-up periods, endometrioma recurrence, and development of ovarian cancer.


Recurrence of endometrioma was recorded in 121 patients (24.9% of the entire cohort), and 4 patients (0.8% of the entire cohort) developed ovarian cancer. All ovarian cancers developed from a recurrent endometrioma (3.3% of patients who experienced recurrence). Recurrence of endometrioma was significantly associated with ovarian cancer development.


Ovarian cancers can develop after excision of endometrioma and are more likely to arise from recurrent endometrioma. Special care such as rigorous follow-up should be practiced to manage patients who experience recurrence of endometrioma.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.