Leydig cell tumor found incidentally during microscopic testicular sperm extraction in patient with mosaic Klinefelter syndrome: case report

Syndromes that cause infertility can affect a patient’s cancer risk. This case is an example of the role of the infertility specialist in identifying an unsuspected testicular tumor.

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Volume 106, Issue 6, Pages 1344-1347

Authors:

Nathan M. Shaw, M.D., Craig Stauffer, M.D., Michael L. Eisenberg, M.D.

Abstract:

Objective

To report the finding and management of a case of Leydig cell tumor discovered during the infertility evaluation of a patient with mosaic Klinefelter syndrome.

Design

Single case report.

Setting

Academic hospital.

Patient(s)

Patient seeking assistance with fertility after a diagnosis of mosaic Klinefelter syndrome.

Intervention(s)

The patient underwent microscopic testicular sperm extraction (mTESE) for sperm identification after the diagnosis of mosaic Klinefelter syndrome. Abnormal testicular tissue was identified during mTESE and histologically confirmed to be a Leydig cell tumor. The patient was informed of this incidental discovery and later underwent orchiectomy for conservative oncologic control.

Main Outcome Measure(s)

Histologic testicular assessment.

Result(s)

Patient was found to have no viable sperm on mTESE, but achieved oncologic control with bilateral orchiectomy.

Conclusion(s)

The presented case emphasizes the importance of awareness and expedient appropriate management to achieve oncologic control of a rare tumor with low malignant potential discovered during otherwise routine mTESE. In particular, it highlights the role of the infertility specialist in aiding in diagnosis and treatment of incidental and rare findings.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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