Pipeline for contraceptive development

This review describes the pipeline of new targets and products under development for male and female contraception. Both hormonal and nonhormonal candidates are under clinical evaluation or in preclinical development.

Volume 106, Issue 6, Pages 1295-1302


Diana L. Blithe, Ph.D.


The high rates of unplanned pregnancy reflect an unmet need for effective contraceptive methods for women, especially for individuals with health risks such as obesity, diabetes, hypertension, and other conditions that may contraindicate use of an estrogen-containing product. Improvements in safety, user convenience, acceptability, and availability of products remain important goals of the contraceptive development program. Another important goal is to minimize the impact of the products on the environment. Development of new methods for male contraception has the potential to address many of these issues of safety for women who have contraindications to effective contraceptive methods but want to protect against pregnancy. It would also address a huge unmet need for men who want to control their fertility. Products under development for men would not introduce ecotoxic hormones into the water system.

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