Fertility outcome of laparoscopic treatment in patients with severe endometriosis and repeated in vitro fertilization failures

Women with severe endometriosis and in vitro fertilization failures may benefit from surgery by specialized surgeons. Young age, normal ovarian response, and normal uterine morphology are good prognostic factors for delivery after surgery.

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Volume 106, Issue 5, Pages 1264-1269


David Soriano, M.D., Iris Adler, M.D., Jerome Bouaziz, M.D., Matti Zolti, M.D., Vered H. Eisenberg, M.D., Mordechai Goldenberg, M.D., Daniel S. Seidman, M.D., Shai E. Elizur, M.D.



To evaluate fertility outcomes in infertile women with severe endometriosis (The revised American Fertility Society classification [AFS] 3–4) and repeated IVF failures, who underwent surgery due to exacerbation of endometriosis-related symptoms.


Retrospective cohort study.


University hospital.


All women who failed IVF treatment before surgery and who underwent laparoscopic surgery for severe endometriosis between January 2006 and December 2014.


All patients were operated by highly skilled surgeons specializing in laparoscopic surgery for advanced endometriosis. Only patients with evidence of endometriosis in the pathology specimens were included in this study.

Main Outcome Measure(s)

Delivery rate after surgery.


Seventy-eight women were included in the present study. All women were diagnosed with severe endometriosis during surgery (AFS 3–4) and all women had experienced failed IVF treatments before surgery. All women were symptomatic before their surgery. After surgical treatment 33 women (42.3%) delivered. Three women (9%) conceived spontaneously and all other women conceived after IVF treatment. Women who delivered were younger (32.5 [±4.1] years vs. 35.5 [±3.8] years), were less often diagnosed with diminished ovarian reserve before surgery (6% vs. 28.8%), and were more often diagnosed with normal uterine anatomy (by preoperative transvaginal ultrasound and during operation). In addition, performing salpingectomy during surgery was associated with a trend of improvement in delivery rates after surgery (70% in women who delivered vs. 51% in women who failed to deliver).


Symptomatic women with severe endometriosis and repeated IVF implantation failures may benefit from extensive laparoscopic surgery when performed by an experienced multidisciplinary surgical team to improve IVF outcome.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.