How compliant are in vitro fertilization member clinics in following embryo transfer guidelines? An analysis of 59,689 fresh first in vitro fertilization autologous cycles from 2011 to 2012

Most first autologous IVF cycles are compliant with Society of Assisted Reproductive Technology guidelines, except those that involved a blastocyst transfer in patients aged <35 years, which resulted in a high multiple pregnancy rate.

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Volume 106, Issue 3, Pages 645-652

Authors:

Sanaz Keyhan, M.D., Kelly S. Acharya, M.D., Chaitanya R. Acharya, M.S., Jason S. Yeh, M.D., Meredith P. Provost, M.D., Ph.D., James M. Goldfarb, M.D., Suheil J. Muasher, M.D.

Abstract:

Objective

To determine whether IVF clinics are compliant with American Society for Reproductive Medicine (ASRM) and Society for Assisted Reproductive Technology (SART) (ASRM/SART) guidelines and assess the multiple pregnancy outcomes according to the number of embryos transferred.

Design

Retrospective cohort study.

Setting

Not applicable.

Patient(s)

Data from 59,689 fresh first autologous IVF cycles from the 2011–2012 SART registry.

Intervention(s)

None.

Main Outcome Measure(s)

Percentage of compliant cycles, multiple pregnancy rate (PR).

Result(s)

Between 2011 and 2012, a total of 59,689 fresh first autologous cycles were analyzed. Among cleavage-stage ET cycles, the noncompliance rate ranged from 10%–27.4% depending on the age group. The multiple PR was significantly increased in noncompliant cycles involving patients <35 years (38.1% vs. 28.7%) and 35–37 years (35.4% vs. 24.5%) compared with compliant cycles. Among blastocyst-stage ET cycles, the highest rate of noncompliance was seen in patients <35 years old (71%), which resulted in a statistically higher multiple PR (48.3% vs. 2.8%) compared with compliant cycles. Far fewer cycles were noncompliant in patients 35–40 years of age. In a subanalysis of compliant cycles, transferring two blastocyst embryos in patients 35–37 years and 38–40 years resulted in a higher live birth rate compared with the transfer of one embryo (50.4% vs. 40.9% and 42.1% vs. 30.0%, respectively) but the multiple PR was also significantly higher (40.5% vs. 1.7% and 34.0% vs. 2.0%, respectively).

Conclusion(s)

Most first fresh autologous IVF cycles performed from 2011–2012 were compliant with ASRM/SART guidelines, except those that involved a blastocyst ET in patients <35 years. Despite compliance, cycles that involved the transfer of >1 embryo resulted in a high multiple PR, whereas noncompliant cycles resulted in an even more remarkable multiple PR for both cleavage and blastocyst-stage embryos. Clinics need to be more compliant with ET limits and ASRM/SART need to consider revising their guidelines to limit the number of blastocyst transfer to one in patients ≤40 years of age undergoing their first IVF cycle. Furthermore, decreasing the number of cleavage-stage embryos transferred in patients ≤40 years of age should also be considered.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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