Genotypically determined ancestry across an infertile population: ovarian reserve and response parameters are not influenced by continental origin

Ovarian reserve parameters including antimullerian hormone, basal antral follicle count, follicle-stimulating hormone, and ovarian response as measured by total oocyte yield are similar among various ethnicities as determined by genotyping.

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Volume 106, Issue 2, Pages 475-480

Authors:

Meir Olcha, M.D., Jason M. Franasiak, M.D., Shefali Shastri, M.D., Thomas A. Molinaro, M.D., Haley Congdon, Nathan R. Treff, Ph.D., Richard T. Scott Jr., M.D.

Abstract:

Objective

To evaluate the relationship between genetic ethnicity using ancestry informative markers (AIMs) and ovarian reserve and response parameters as evidenced by FSH, antimüllerian hormone (AMH), basal antral follicle count (BAFC), and total oocyte yield in IVF.

Design

Retrospective.

Setting

Academic medical center.

Patients(s)

A total of 2,508 infertile patients undergoing IVF at a single center.

Intervention(s)

Patients were genotyped for 32 AIMs and analyzed for differences in allele frequencies. A validated Bayesian clustering algorithm was then used to assign individuals into one of four ethnic populations: European, African, Central/South Asian, or East Asian.

Main Outcome Measure(s)

FSH, AMH, BAFC, and oocyte yield variation.

Result(s)

After controlling for age and body mass index, genetic ethnicity had no impact on AMH, BAFC, and oocyte yield. FSH was found to be lower in patients of Central/South Asian ancestry (6.46 ng/mL vs. 6.97 ng/mL); however, the absolute difference is of little clinical significance. Subgroup analyses of 1,327 patients restricted to those with limited genetic admixture as determined by AIMs indicated that FSH, AMH, BAFC, and oocyte yield were equivalent.

Conclusion(s)

When determining ethnicity using AIMs, ethnic background does not have an impact on markers of ovarian reserve or ovarian response. Specifically, no differences were found in AMH, BAFC, or oocyte yield relative to genotypic ethnicity. Using AIMs rather than self-reported ethnicity allows for elimination of reporting biases and nonreporting of ethnicity, which can confound data. Based upon these data, specific recommendations for ovarian reserve testing should thus be made based on other factors besides ethnic background.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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