Fertility problems and risk of gestational diabetes mellitus: a nationwide cohort study

Pregnant women with fertility problems are at increased risk of gestational diabetes mellitus, independently from maternal characteristics including maternal age, prepregnancy body mass index, and other potential confounding factors.

Like Comment

Volume 106, Issue 2, Pages 427-434


Signe Holst, M.Sc., Susanne K. Kjær, D.M.Sc., Marit E. Jørgensen, Ph.D., Peter Damm, D.M.Sc., Allan Jensen, Ph.D.



To determine whether women with a history of fertility problems have a higher risk of gestational diabetes mellitus (GDM) than women without a history of fertility problems after adjustment for maternal factors.


Nationwide population-based cohort study.


Not applicable.


All live and stillbirths during 2004–2010 among women with fertility problems (n = 49,616) and women without fertility problems (n = 323,061) were identified by linkage between the Danish Medical Birth Registry and the Danish Infertility Cohort. Information on GDM was obtained from the Danish National Patient Registry.



Main Outcome Measure(s)

Odds ratios and 95% confidence intervals for the association between fertility problems and risk of GDM after adjustment for potentially confounding factors, including maternal age, prepregnancy BMI, parity, parental history of diabetes, level of education, and smoking during pregnancy.


In total, 7,433 (2%) pregnant women received a diagnosis of GDM. Multivariate analysis showed that pregnant women with a history of fertility problems had a statistically significantly higher risk of GDM than pregnant women without fertility problems. In stratified analyses, the association between fertility problems and risk of GDM attenuated with increasing age and was more pronounced among primiparous women and women with polycystic ovary syndrome.


Our findings suggest that pregnant women with a history of fertility problems are at increased risk of GDM.

Read the full text here.

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.