Trends and outcomes of gestational surrogacy in the United States

The practice of gestational surrogacy is increasing in the United States. Higher multiple birth rates among gestational carriers may be mitigated by transferring fewer embryos.

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Volume 106, Issue 2, Pages 435-442

Authors:

Kiran M. Perkins, M.D., M.P.H., Sheree L. Boulet, Dr.P.H., Denise J. Jamieson, M.D., M.P.H., Dmitry M. Kissin, M.D., M.P.H. for the National Assisted Reproductive Technology Surveillance System (NASS) Group

Centers for Disease Control and Prevention, Division of Reproductive Health, Atlanta, Georgia

Abstract:

Objective

To evaluate trends and reproductive outcomes of gestational surrogacy in the United States.

Design

Retrospective cohort study.

Setting

Infertility clinics.

Patient(s)

IVF cycles transferring at least one embryo.

Intervention(s)

Use of a gestational carrier.

Main Outcome Measure(s)

Trends in gestational carrier cycles during 1999–2013, overall and for non-U.S. residents; reproductive outcomes for gestational carrier and nongestational carrier cycles during 2009–2013, stratified by the use of donor or nondonor oocytes.

Result(s)

Of 2,071,984 assisted reproductive technology (ART) cycles performed during 1999–2013, 30,927 (1.9%) used a gestational carrier. The number of gestational carrier cycles increased from 727 (1.0%) in 1999 to 3,432 (2.5%) in 2013. Among gestational carrier cycles, the proportion with non-U.S. residents declined during 1999–2005 (9.5% to 3.0%) but increased during 2006–2013 (6.3% to 18.5%). Gestational carrier cycles using nondonor oocytes had higher rates of implantation (adjusted risk ratio [aRR], 1.22; 95% confidence interval [CI], 1.17–1.26), clinical pregnancy (aRR, 1.14; 95% CI, 1.10–1.19), live birth (aRR, 1.17; 95% CI, 1.12–1.21), and preterm delivery (aRR, 1.14; 95% CI, 1.05–1.23) compared with nongestational carrier cycles. When using donor oocytes, multiple birth rates were higher among gestational carrier compared with nongestational carrier cycles (aRR, 1.13; 95% CI, 1.08–1.19).

Conclusion(s)

Use of gestational carriers increased during 1999–2013. Gestational carrier cycles had higher rates of ART success than nongestational carrier cycles, but multiple birth and preterm delivery rates were also higher. These risks may be mitigated by transferring fewer embryos given the higher success rates among gestational carrier cycles.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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