Risk of miscarriage in women with endometriosis: insights from in vitro fertilization cycles

Women with endometriosis achieving singleton pregnancies with IVF do not have an increased risk of miscarriage.

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Volume 106, Issue 2, Pages 386-392

Authors:

Marta Leonardi, M.D., Enrico Papaleo, M.D., Marco Reschini, M.Sc., Luca Pagliardini, M.D., Laura Benaglia, M.D., Giorgio Candotti, M.D., Paola Viganó, D.Sc., Ph.D., Lavinia Quaranta, M.D., Maria Munaretto, M.D., Massimo Candiani, M.D., Paolo Vercellini, M.D., Edgardo Somigliana, M.D.

Abstract:

Objective

To evaluate whether women with endometriosis achieving singleton pregnancies with IVF face an increased risk of miscarriage.

Design

Matched case-control study.

Setting

Infertility units.

Patient(s)

Women achieving singleton pregnancies with the use of IVF were considered. Cases were women with a history of surgery for endometriosis and those who were documented the presence of ovarian endometriomas at the time of the IVF cycle (n = 313). Controls were matched to cases by age (±6 months), type of cycle (fresh or frozen cycle). and study period (n = 313).

Intervention(s)

Retrospective review of women undergoing IVF.

Main Outcome Measure(s)

Rate of miscarriage before 12 weeks’ gestation.

Result(s)

The number of miscarriages in women with and without endometriosis was similar, being 48 (15%) and 60 (19%), respectively. The odds ratio of miscarriage in affected women was 0.76 (95% confidence interval 0.50–1.16). The odds ratio adjusted for body mass index (BMI), parity, duration of infertility, and male factor infertility was 0.81 (95% confidence interval 0.53–1.25). Subgroup analyses according to the type of cycle, the number of embryos transferred, the presence of endometriomas, and the history of surgery for endometriosis did not document any subgroup at significant increased risk of miscarriage.

Conclusion(s)

The risk of miscarriage is not increased in women with endometriosis achieving pregnancy with the use of IVF.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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