Small follicles may be a promising source of oocytes in modified natural cycle in vitro fertilization–embryo transfer



Zeev Blumenfeld, M.D.


The recent study by Teramoto et al. (1) has shown that nondominant small follicles are a promising supplementary source of in vivo matured oocytes, and their use may increase the live-birth rate in natural cycle in vitro fertilization (IVF). The investigators have retrospectively evaluated 771 infertile patients who underwent natural cycle IVF during a 2-year period. When the leading, dominant follicle reached a diameter of 16–18 mm, they triggered an endogenous luteinizing hormone (LH) surge via a nasally administered gonadotropin-releasing hormone (GnRH) agonist (buserelin) and aspirated all the follicles of 3-mm diameter or larger after aspirating the dominant follicle.

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