Increasing serum 25-hydroxyvitamin D is associated with reduced odds of long menstrual cycles in a cross-sectional study of African American women

Increasing serum 25-hydroxyvitamin D is associated with reduced odds of long menstrual cycles in African American women. A growing body of evidence suggests that vitamin D is important for ovarian function.

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Authors

Anne Marie Z. Jukic, Ph.D.correspondenceemail, Kristen Upson, Ph.D., Quaker E. Harmon, M.D., Ph.D., Donna D. Baird, Ph.D.

Abstract

Objective

To examine the association between serum 25-hydroxyvitamin D [25(OH)D] and menstrual cycle length and regularity.

Design

Community-based, cross-sectional study of serum 25(OH)D (adjusted for seasonal differences in timing of blood draw) and menstrual cycle length. Women aged 23–34 years reported their gynecologic history. Menstrual cycles were described with four independent categories (normal, short, long, irregular). We used polytomous logistic regression to estimate the association between a doubling of seasonally adjusted 25(OH)D and the odds of each cycle category.

Setting

Not applicable.

Patient(s)

A total of 1,102 African American women.

Intervention(s)

Not applicable.

Main Outcome Measure(s)

Self-reported menstrual cycle length over the previous 12 months, excluding women who were using cycle-regulating medications over the entire year. Women who reported that their cycles were “too irregular to estimate” were classified as having irregular cycles. A typical cycle length of <27 days was considered “short,” >34 days was “long,” and 27–34 days was “normal.”

Result(s)

The median 25(OH)D level was 14.7 ng/mL (interquartile range, 10.9–19.6 ng/mL). A doubling of 25(OH)D was associated with half the odds of having long menstrual cycles: adjusted odds ratio (aOR) 0.54, 95% confidence interval (CI) 0.32–0.89. 25-Hydroxyvitamin D was not associated with the occurrence of short (aOR 1.03, 95% CI 0.82–1.29) or irregular (aOR 1.46, 95% CI 0.88–2.41) menstrual cycles. Results were robust to several sensitivity analyses.

Conclusion(s)

These findings suggest that vitamin D status may influence the menstrual cycle and play a role in ovarian function. Further investigation of 25(OH)D and ovarian hormones, and prospective studies of 25(OH)D and cycle length, are needed.

Read the full text at: http://www.fertstert.org/article/S0015-0282(16)300...

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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