Impact of female age and nulligravidity on fecundity in an older reproductive age cohort

Women experience a significant reduction in fecundity and an increase in the probability of infertility in the late thirties. At any age >30 years, women, who have never conceived before, have a lower probability of conception.

Like Comment

Authors

Anne Z. Steiner, M.D., M.P.H., Anne Marie Z. Jukic, Ph.D.

Volume 105, Issue 6, Pages 1584-1588

Abstract

Objective:

To provide female age-related estimates of fecundity and incidence of infertility by history of prior pregnancy among women 30–44 years of age.

Design:

Prospective, time-to-pregnancy cohort study.

Setting:

Not applicable.

Patient(s):

Women, between 30 and 44 years of age, attempting to conceive for ≤3 months, and no known history of infertility, polycystic ovarian syndrome (PCOS), or endometriosis.

Intervention(s):

Not applicable.

Main Outcome Measure(s):

Fecundability and incidence of infertility.

Result(s):

Compared to women aged 30–31 years, fecundability was reduced by 14% in women 34–35 years of age (fecundability ratio [FR] 0.86, 95% confidence interval [CI] 0.68–1.08), 19% in women 36–37 years of age (FR 0.81, 95% CI 0.60–1.08, 30% in women 38–39 years of age (FR 0.70, 95% CI 0.48–1.01), 53% in women 40–41 years of age (FR 0.47, 95% CI 0.28–0.78), and 59% in women 42–44 years of age (FR 0.39, 95% CI 0.16–0.93). Fecundability did not differ between women aged 30–31 years and 32–33 years. In general, fecundability and cumulative probability of pregnancy was lower for women who had never had a prior pregnancy.

Conclusion(s):

Women experience a significant reduction in fecundity and increase in the probability of infertility in their late thirties. At any age >30 years, women who have never conceived have a lower probability of achieving a pregnancy.

Clinical Trial Registration Number:

NCT01028365.

Read the full text at: http://www.fertstert.org/article/S0015-0282(16)00152-7/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.