Diminished ovarian reserve: is it a neglected cause in the assessment of recurrent miscarriage? A cohort study

Diminished ovarian reserve may be a hidden cause for recurrent miscarriage regardless of maternal age.

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Melahat Atasever, M.D., Zeynep Soyman, M.D., Emine Demirel, M.D., Servet Gencdal, M.D., Sefa Kelekci, M.D.

Volume 105, Issue 5, Pages 1236-1240



To study whether diminished ovarian reserve is associated with recurrent miscarriage.


Cross-sectional clinical study.


Tertiary-care center.


Women with history of recurrent miscarriage (RM; n = 71) and sequentially selected age-matched fertile women who were seeking contraception (control; n = 70).



Main Outcome Measures(s):

Serum levels of FSH, LH, E2, and antimüllerian hormone (AMH); FSH/LH ratio; ovarian volumes; and antral follicle count (AFC).


The levels of FSH were 8.6 ± 3.7 U/L in the RM group and 7.1 ± 3.9 U/L in the control group; this difference was statistically significant. The levels of AMH were significantly lower in the RM group than in the control group (2.9 ± 1.7 ng/mL vs. 3.6 ± 1.7 ng/mL). The percentage of women with levels of FSH ≥11 U/L was significantly higher in the RM group than in the control group (18.3% vs. 4.3%). In the RM group, the percentage of women with levels of AMH ≤1 ng/mL was significantly higher than in the control group (19.7% vs. 5.7%).


Recurrent miscarriage may be associated with diminished ovarian reserve. Larger prospective randomized controlled trials are warranted to better determine the predictive potential of ovarian reserve markers in recurrent miscarriage.

Read the full text at: http://www.fertstert.org/article/S0015-0282(16)00036-4/fulltext

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.