The challenge of embryonic mosaicism in preimplantation genetic screening

The availability of reliable 24 chromosome aneuploidy screening platforms has provided clinicians and scientists with a powerful new diagnostic tool in the embryology laboratory. Class I data demonstrate increased implantation and delivery rates and reduced multiple gestation rates by empowering more effective single ET after preimplantation genetic screening (PGS) is performed on trophectoderm biopsies (1, 2). Sustained implantation rates of 60% or higher are routinely being attained in multiple programs after synchronous transfer of euploid blastocysts—even in women in their early forties.

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Authors

Richard T. Scott Jr., M.D., Daniela Galliano, M.D.

Volume 105, Issue 5, Pages 1150-1152

Abstract

The availability of reliable 24 chromosome aneuploidy screening platforms has provided clinicians and scientists with a powerful new diagnostic tool in the embryology laboratory. Class I data demonstrate increased implantation and delivery rates and reduced multiple gestation rates by empowering more effective single ET after preimplantation genetic screening (PGS) is performed on trophectoderm biopsies (1, 2). Sustained implantation rates of 60% or higher are routinely being attained in multiple programs after synchronous transfer of euploid blastocysts—even in women in their early forties.

Read the full text at: http://www.fertstert.org/article/S0015-0282(16)00042-X/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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