Endometriosis related infertility: assisted reproductive technology has no adverse impact on pain and quality of life scores

Assisted reproduction technology has no adverse impact on pain symptoms or quality of life in women with endometriosis of any phenotype as compared with healthy women.


Pietro Santulli, M.D., Ph.D., Mathilde Bourdon, Marion Presse, Vanessa Gayet, M.D., Louis Marcellin, M.D., Caroline Prunet, Dominique de Ziegler, M.D., Charles Chapron, M.D.

Volume 105, Issue 4, Pages 978-987



To evaluate the impact of assisted reproduction technology (ART) on painful symptoms and quality of life (QoL) in women who have endometriosis as compared with disease-free women.


Prospective controlled, observational cohort study.


University hospital.


Two hundred and sixty-four matched-pairs of endometriosis and disease-free women undergoing ART.


Assessment of pain evolution using visual analogue scale (VAS) during ART; QoL assessment with the Fertility Quality of Life (FertiQoL) tool.

Main Outcome Measure(s):

VAS pain intensities relative to dysmenorrhea, dyspareunia, noncyclic chronic pelvic pain (NCCPP), gastrointestinal pain, lower urinary tract pain; trends for VAS change between postretrieval and baseline evaluation; FertiQoL score; and statistical analyses conducted using univariate and adjusted multiple linear regression models.


After excluding canceled cycles and patients lost to follow-up observation, 102 women with endometriosis and 104 disease-free women were retained for the study. The trends for VAS change between the postretrieval and baseline evaluations in the women with endometriosis compared with the disease-free women revealed a statistically significant pain decrease for dysmenorrhea (−1.35 ± 3.23 and 0.61 ± 4.00) and dyspareunia (−1.19 ± 2.58 and 0.14 ± 2.06). For NCCPP, gastrointestinal symptoms, and lower urinary tract symptoms, there were no statistically significant differences between the groups. After multiple linear regression, no worsening of pain was observed in the endometriosis group as compared with disease-free group. In addition subgroup analysis according to endometriosis phenotype failed to show any increase of pain. The quality of life in the endometriosis group was comparable to that of the disease-free group.


Assisted reproduction technology did not exacerbate the symptoms of endometriosis or negatively impact QoL in women with endometriosis as compared with disease-free women.

Read the full text at: http://www.fertstert.org/article/S0015-0282(15)02175-5/fulltext

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