Authors

Ana Cobo, Ph.D., Nicolás Garrido, Ph.D., M.Sc., Antonio Pellicer, M.D., José Remohí, M.D.

Volume 104, Issue 6, Pages 1426-1434

Abstract

Objective:

To describe the clinical outcomes achieved after 6 years’ experience in ovum donation conducted with vitrified oocytes to attempt to find predictors of survival; and to provide information about the probability of having a baby according to the number of oocytes consumed.

Design:

Retrospective, observational study.

Setting:

Private university-affiliated in vitro fertilization center.

Patient(s):

Recipients of vitrified oocytes (January 2007–March 2013), including all the warming procedures (n = 3,610) and all the donations made during the same period (n = 3,467).

Intervention(s):

None.

Main Outcome Measure(s):

Survival rate per warming procedure, cumulative delivery rates (CDR) per single donation cycle, oocyte-to-baby rate, and cumulative live birth rate (CLBR) per oocyte consumed.

Result(s):

Oocyte survival rate was 90.4%. It was not possible to develop a predictive model for survival owing to the lack of prognostic value of the studied variables. Implantation, clinical, and ongoing pregnancy rates per donation cycle were 39.0% (95% confidence interval [CI], 37.8–40.5), 48.4% (95% CI, 46.7–50.1), and 39.9% (95% CI, 38.3–41.5), respectively. Statistical differences were found when comparing blastocysts versus day 3 ETs (42.5%; 95% CI, 40.4–45.2 vs. 37.5%; 95% CI, 35.3–39.7 ongoing pregnancy rate). The CDR/donation cycle, including cryotransfers, was 78.8% (95% CI, 73.5–84.1). The oocyte-to-baby rate was 6.5%. CLBR increased progressively according to the number of oocytes consumed.

Conclusion(s):

We provide detailed information about the high efficiency of using vitrified/warmed oocytes. There is currently no way of estimating donors’ oocytes survival when considering baseline characteristics, storage time, or controlled ovarian syndrome parameters. The probability of achieving a baby using vitrified oocytes increases progressively with the number of oocytes consumed.

Read the full text at: http://www.fertstert.org/article/S0015-0282(15)01866-X/fulltext