Six years experience in ovum donation using vitrified oocytes Report of cumulative outcomes impact of storage time and development of a predictive model for oocyte survival rate

Oocyte banking is clinically efficient. Estimation of the likelihood of having a child is provided. There is no way of estimating donors’ oocytes survival when considering baseline characteristics, storage time, or controlled ovarian stimulation parameters.

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Authors

Ana Cobo, Ph.D., Nicolás Garrido, Ph.D., M.Sc., Antonio Pellicer, M.D., José Remohí, M.D.

Volume 104, Issue 6, Pages 1426-1434

Abstract

Objective:

To describe the clinical outcomes achieved after 6 years’ experience in ovum donation conducted with vitrified oocytes to attempt to find predictors of survival; and to provide information about the probability of having a baby according to the number of oocytes consumed.

Design:

Retrospective, observational study.

Setting:

Private university-affiliated in vitro fertilization center.

Patient(s):

Recipients of vitrified oocytes (January 2007–March 2013), including all the warming procedures (n = 3,610) and all the donations made during the same period (n = 3,467).

Intervention(s):

None.

Main Outcome Measure(s):

Survival rate per warming procedure, cumulative delivery rates (CDR) per single donation cycle, oocyte-to-baby rate, and cumulative live birth rate (CLBR) per oocyte consumed.

Result(s):

Oocyte survival rate was 90.4%. It was not possible to develop a predictive model for survival owing to the lack of prognostic value of the studied variables. Implantation, clinical, and ongoing pregnancy rates per donation cycle were 39.0% (95% confidence interval [CI], 37.8–40.5), 48.4% (95% CI, 46.7–50.1), and 39.9% (95% CI, 38.3–41.5), respectively. Statistical differences were found when comparing blastocysts versus day 3 ETs (42.5%; 95% CI, 40.4–45.2 vs. 37.5%; 95% CI, 35.3–39.7 ongoing pregnancy rate). The CDR/donation cycle, including cryotransfers, was 78.8% (95% CI, 73.5–84.1). The oocyte-to-baby rate was 6.5%. CLBR increased progressively according to the number of oocytes consumed.

Conclusion(s):

We provide detailed information about the high efficiency of using vitrified/warmed oocytes. There is currently no way of estimating donors’ oocytes survival when considering baseline characteristics, storage time, or controlled ovarian syndrome parameters. The probability of achieving a baby using vitrified oocytes increases progressively with the number of oocytes consumed.

Read the full text at: http://www.fertstert.org/article/S0015-0282(15)01866-X/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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