Live birth following in vitro maturation of oocytes retrieved from extracorporeal ovarian tissue aspiration and embryo cryopreservation for 5 years

Extracorporeal aspiration of immature oocytes from ovarian tissue, in vitro maturation, embryo cryopreservation, and a delayed frozen embryo transfer ultimately led to a live birth.

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Peter S. Uzelac, M.D., Abigail A. Delaney, M.D., Greg L. Christensen, Ph.D., Henry C.L. Bohler, M.D., Steven T. Nakajima, M.D.

Volume 104, Issue 5, Pages 1258-1260



To report a live birth after in vitro maturation (IVM) of oocytes retrieved from extracorporeal ovarian tissue aspiration in the setting of fertility preservation.


Observational study.


Academic center.


A 23-year-old woman.


IVM from extracorporeal ovarian tissue aspiration.

Main Outcome Measure(s):

Live birth after IVM.


A 23-year-old woman conceived with embryos derived from extracorporeal oocyte aspiration followed by IVM, embryo freezing, and frozen embryo transfer.


A healthy live birth from extracorporeal aspiration of immature oocytes, IVM, and a frozen embryo transfer after 5 years was documented. Consideration of this technique should be made as a primary or adjunct intervention in the setting of fertility preservation.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.