Benefits of pregnancy on endometriosis: can we dispel the myths?
Article In Press
Brigitte Leeners, M.D.a, Cynthia M. Farquhar, MB.Ch.B., M.D., M.P.H.b,c
Regression of endometriotic lesions during pregnancy was first described by Sampson in 1921. Since that time pregnancy has often been recommended by health professionals as a useful strategy to reduce disease progression and symptoms. Lack of symptoms before menarche and after menopause, both associated with amenorrhoea, further supported the hypothesis that pregnancy was beneficial. Progesterone induces endometrial atrophy and endometriotic lesions show cyclic changes such as endometrial growth and luteal transformation throughout the menstrual cycle.