Low antimüllerian hormone (AMH) is associated with decreased live birth after in vitro fertilization when follicle-stimulating hormone and AMH are discordant
Low AMH (<1 ng/mL) with normal FSH is associated with decreased live birth and higher cycle cancellation compared with normal AMH and elevated FSH (>10 mIU/mL) in women undergoing IVF.
Volume 112, Issue 1, Pages 73–81.e1
Sarah Ligon, M.D., Michael Lustik, M.S., Gary Levy, M.D., Bruce Pier, M.D.
To evaluate which factor, AMH or FSH, was superior in predicting live birth after assisted reproductive technologies (ART) when the tests are discordant, using data from the Society for Assisted Reproductive Technology Clinical Outcomes Reporting System database.
The study population included 44,696 fresh embryo transfer cycles using autologous oocytes.
Main Outcome Measure(s)
Live birth (≥22 wk gestation and ≥300 g birth weight).
Live birth rate per started cycle was lower in patients with low AMH and normal FSH than in patients with normal AMH and elevated FSH (26% vs. 39%). A multivariate analysis was performed on patients with normal FSH and low AMH, and the following factors were independently associated with live birth: AMH, age >40 years, body mass index >30 kg/m2, race African-American or Asian, IVF clinic region West, uterine factor infertility diagnosis, agonist suppression, and FSH dosage. IVF cycle cancellation rate was higher in patients with low AMH and normal FSH (30%).
AMH is a superior predictor of live birth in patients undergoing IVF when FSH and AMH values are discordant. Lower AMH is independently associated with lower live birth and higher IVF cycle cancellation rates than elevated FSH in patients with discordant values.