Children born to women with polycystic ovary syndrome—short- and long-term impacts on health and development
Article In Press
Eszter Vanky, M.D., Ph.D., Liv Guro Engen Hanem, M.D., David H. Abbott, Ph.D.
Maternal PCOS status may negatively influence offspring infant and childhood growth, cardiometabolic health, reproductive health, and neurodevelopment. Current findings across studies are divergent, often because of small numbers of subjects, as well as heterogeneous selection criteria, ethnicities, and definitions of control groups. Coexisting maternal obesity, pregnancy complications, and comorbidity make it difficult to identify the contribution of maternal PCOS. Large, prospective, international, multiethnic studies with standardized investigation protocols and questionnaires on PCOS offspring health and development are needed.