Outcome of ovarian stimulation for oocyte cryopreservation in women with Turner syndrome

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Authors:

Vikram Sinai Talaulikar, Ph.D., Gerard S. Conway, Ph.D., Antoinette Pimblett, M.Sc., Melanie C. Davies, M.A.

Abstract:

Objective

To study the safety and efficacy of ovarian stimulation and oocyte cryopreservation as a method of fertility preservation in women with Turner syndrome (TS).

Design

Retrospective cohort study.

Setting

Reproductive medicine clinic.

Patient(s)

Seven women with TS who attended the clinic between 2011 and 2017.

Intervention(s)

Ovarian stimulation and oocyte cryopreservation.

Main Outcomes Measure(s)

Number of oocytes cryopreserved, ovarian hyperstimulation syndrome.

Result(s)

The oocyte retrieval rates (mean ± SD, 9 ± 3.16) in women with TS were comparable to the published data from healthy women. The oocyte yield was higher than expected based on the low antimüllerian hormone levels. There was no correlation between baseline antimüllerian hormone or antral follicle count levels and the number of oocytes retrieved.

Conclusion(s)

Oocyte cryopreservation after ovarian stimulation appears to be safe and successful in women with mosaic TS who wish to consider fertility preservation.



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