Higher luteinizing hormone levels associated with antimüllerian hormone in postmenarchal daughters of women with polycystic ovary syndrome

Higher LH secretion associated with antimullerian hormone in postmenarchal daughters of women with polycystic ovary syndrome supports the mechanism of inherited neuroendocrine dysfunction recently shown in animal models.

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Volume 111, Issue 2, Pages 372–380

Authors:

Nicolás Crisosto, Ph.D., M.D., Amanda Ladrón de Guevara, M.D., Bárbara Echiburú, M.Sc., Manuel Maliqueo, Ph.D., Gabriel Cavada, Ph.D., Ethel Codner, M.D., Francisco Paez, M.D., Teresa Sir-Petermann, Ph.D., M.D.

Abstract:

Objective

To study the reproductive and metabolic differences between daughters of women with polycystic ovary syndrome (PCOSd) and control women (Cd) after menarche.

Design

Case-control study.

Setting

Clinical endocrinology unit.

Patient(s)

We studied 43 PCOSd and 28 Cd 1.5–6 years after menarche.

Intervention(s)

Determination of anthropometry, pubertal development, hirsutism, oral glucose tolerance test, and GnRH analogue test.

Main Outcome Measure(s)

Ferriman score, sex steroids, gonadotropins, antimüllerian hormone (AMH), ovarian volumes, and glucose and insulin levels.

Result(s)

The groups were similar in chronologic, gynecologic, and menarchal ages and anthropometric variables. Ferriman score, ovarian volumes, and AMH were higher in PCOSd. Propensity score analysis showed that there were significant differences in LH, LH-FSH ratio, T and free androgen index, post-stimulated LH and LH-FSH ratio, and 2-hour insulin that could be attributed only to the fact of being a PCOS daughter. The generalized linear model showed that higher LH levels were positively associated with AMH and T levels.

Conclusion(s)

We found that higher LH, androgen, and insulin levels are present in PCOSd during the postmenarchal period, which may establish the basis for the development of PCOS during adulthood. Moreover, LH levels were associated with AMH levels, which supports that the neuroendocrine feedback proposed for AMH and LH is present in humans and that this feature is probably programed in utero, as recently shown in mice.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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