Proposal for a national registry to monitor women with Turner syndrome seeking assisted reproductive technology

Many women with Turner syndrome (TS) are eager to become pregnant. A small number (5%–10%) will have a spontaneous pregnancy, an outcome thought to be more likely in women with mosaicism (1). The increased availability of oocyte donation (OD) through assisted reproductive technology (ART) has enabled an unknown number of women with TS to achieve a pregnancy. A gathering body of evidence, however, suggests that pregnancy is high risk, secondary to potential aortic dissection and rupture and a significant risk of developing hypertensive disorders of pregnancy.

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Authors

Angela E. Lin, M.D., Megan F. Karnis, M.D., Laurel Calderwood, M.S., C.G.C., Melissa Crenshaw, M.D., Ami Bhatt, M.D., Irene Souter, M.D., Michael Silberbach, M.D., Richard H. Reindollar, M.D.

Volume 105, Issue 6, Pages 1446-1448

Abstract

Many women with Turner syndrome (TS) are eager to become pregnant. A small number (5%–10%) will have a spontaneous pregnancy, an outcome thought to be more likely in women with mosaicism (1). The increased availability of oocyte donation (OD) through assisted reproductive technology (ART) has enabled an unknown number of women with TS to achieve a pregnancy. A gathering body of evidence, however, suggests that pregnancy is high risk, secondary to potential aortic dissection and rupture and a significant risk of developing hypertensive disorders of pregnancy.

Read the full text at: http://www.fertstert.org/article/S0015-0282(16)00083-2/fulltext


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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