We discuss whether efficient transduction and subsequent elimination of fibroid tumor-initiating stem cells during debulking of tumor cells will aid in completely eradicating the tumor as well as decreasing the likelihood of recurrence.
This study discusses the expression of gonadotropin-releasing hormone (GnRH) and its receptor at tubal ectopic pregnancy implantation sites, and investigates the role of GnRH and a GnRH antagonist in regulating trophoblastic BeWo cell viability.
P450c17 deficiency due to inactivating CYP17A1 mutation in 46,XX patients is associated with primary or secondary amenorrhea, absent/sparse pubic hair, hypertension, and high prevalence of ovarian macrocysts with a risk of torsion. In patients with hypergonadotropic hypogonadism, high basal progesterone level is a hallmark for this diagnosis.
Among obese girls with polycystic ovary syndrome, 27% who are metabolically healthy have a more favorable risk profile for type 2 diabetes, atherogenesis, inflammation, and androgenemia compared with the 73% who are metabolically unhealthy.
Women experience a significant reduction in fecundity and an increase in the probability of infertility in the late thirties. At any age >30 years, women, who have never conceived before, have a lower probability of conception.
Age, duration of infertility, income, and a history of prior pregnancy loss were significantly associated with the probability of live birth in women with unexplained infertility undergoing ovarian stimulation–intrauterine insemination.
The available literature on the treatment of unexplained infertility reflects the heterogeneity of clinical practice. Adequately powered, randomized trials are needed to directly compare the efficacy of these treatments.
This study of the hypothalamus-hypophysis-gonad axis in children and adolescents with nonmosaic triple X syndrome found that Triple X patients showed premature activation of the gonadotropin-releasing hormone pulse generator and reduced gonadal function.
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