We discuss whether efficient transduction and subsequent elimination of fibroid tumor-initiating stem cells during debulking of tumor cells will aid in completely eradicating the tumor as well as decreasing the likelihood of recurrence.

Adhesion fibroblasts manifested an altered metabolic profile as compared with normal peritoneal fibroblasts, which favors the glycolytic pathway, and is further altered by hypoxia.

This study discusses the expression of gonadotropin-releasing hormone (GnRH) and its receptor at tubal ectopic pregnancy implantation sites, and investigates the role of GnRH and a GnRH antagonist in regulating trophoblastic BeWo cell viability.

P450c17 deficiency due to inactivating CYP17A1 mutation in 46,XX patients is associated with primary or secondary amenorrhea, absent/sparse pubic hair, hypertension, and high prevalence of ovarian macrocysts with a risk of torsion. In patients with hypergonadotropic hypogonadism, high basal progesterone level is a hallmark for this diagnosis.

Among obese girls with polycystic ovary syndrome, 27% who are metabolically healthy have a more favorable risk profile for type 2 diabetes, atherogenesis, inflammation, and androgenemia compared with the 73% who are metabolically unhealthy.

A diagnosis of depression, anxiety, or treatment with antidepressants before an in vitro fertilization cycle had a slight negative association with pregnancy and live birth but not miscarriage.

Gonadotropin-releasing hormone antagonist used with multifollicular stimulation allows high delivery rates in intrauterine insemination.

Women experience a significant reduction in fecundity and an increase in the probability of infertility in the late thirties. At any age >30 years, women, who have never conceived before, have a lower probability of conception.

Age, duration of infertility, income, and a history of prior pregnancy loss were significantly associated with the probability of live birth in women with unexplained infertility undergoing ovarian stimulation–intrauterine insemination.

The available literature on the treatment of unexplained infertility reflects the heterogeneity of clinical practice. Adequately powered, randomized trials are needed to directly compare the efficacy of these treatments.

Recurrent adnexal torsion is more common when the first torsion episode occurs in the premenarchal period and involves otherwise normal adnexa.

We investigated a biracial cohort of women at the end of their reproductive life. Carrying the apolipoprotein E*2 allele was a risk factor for pregnancy loss only in white women.

This study of the hypothalamus-hypophysis-gonad axis in children and adolescents with nonmosaic triple X syndrome found that Triple X patients showed premature activation of the gonadotropin-releasing hormone pulse generator and reduced gonadal function.

FMR1 CGG repeat lengths within the normal range were not independently associated with ovarian stimulation response or assisted reproduction outcomes.

Our study validated multiple annealing and looping-based amplification cycle next-generation sequencing for 24-chromosome aneuploidy screening of blastocysts.

The histology, ultrastructure, and viability of follicles and stromal cells are better preserved after vitrification of human ovarian cortical strips with slush nitrogen compared with liquid nitrogen.

Inequities exist within state insurance laws that mandate coverage for infertility care. Only 8 of 15 state laws include coverage for male partners, placing undue burden on the female partner.

The study found that cancerous tissues of female reproductive tissues, uterine polyps, and those collected from women with a history of smoking are characterized by altered metals status.

Higher pretreatment whole grain intake was related to a higher probability of live birth among women undergoing in vitro fertilization.

Expression of hypoxia inducible factor 1a and vascularization status in peri-implantation endometrium is altered in the nonconception cycles of women with a history of recurrent miscarriage.