May 2016

All the papers from the May 2016 issue of Fertility and Sterility.

The relationship between recurrent pregnancy loss and the male contribution

Sometimes one looks to the past 50 years in the field of reproductive medicine with veneration and recognition of truly amazing scientific progress. Other times, however, one must humbly acknowledge that despite the remarkable innovations over these years, there are still open questions. In the May 1966 issue of Fertility and Sterility, there was an article by C.A. Joel titled, “New etiologic aspects of habitual abortion and infertility, with special reference to the male factor” (1). An article in the January 2016 issue of Fertility and Sterility examined the same idea: the relationship between recurrent pregnancy loss and sperm characteristics (2). Despite the improvements and advances in the field, 50 years later, this relationship has yet to be expounded.

The challenge of embryonic mosaicism in preimplantation genetic screening

The availability of reliable 24 chromosome aneuploidy screening platforms has provided clinicians and scientists with a powerful new diagnostic tool in the embryology laboratory. Class I data demonstrate increased implantation and delivery rates and reduced multiple gestation rates by empowering more effective single ET after preimplantation genetic screening (PGS) is performed on trophectoderm biopsies (1, 2). Sustained implantation rates of 60% or higher are routinely being attained in multiple programs after synchronous transfer of euploid blastocysts—even in women in their early forties.