Sometimes one looks to the past 50 years in the field of reproductive medicine with veneration and recognition of truly amazing scientific progress. Other times, however, one must humbly acknowledge that despite the remarkable innovations over these years, there are still open questions. In the May 1966 issue of Fertility and Sterility, there was an article by C.A. Joel titled, “New etiologic aspects of habitual abortion and infertility, with special reference to the male factor” (1). An article in the January 2016 issue of Fertility and Sterility examined the same idea: the relationship between recurrent pregnancy loss and sperm characteristics (2). Despite the improvements and advances in the field, 50 years later, this relationship has yet to be expounded.