Recent technical and technologic innovations have allowed overcoming even severe stenosis of the cervix with the use of office hysteroscopy, thus significantly reducing the rate of failed procedures requiring a further inpatient hysteroscopy.

Protected manual in-bag morcellation may be considered efficient and feasible in that it does not interfere with surgical outcomes in women undergoing laparoscopic myomectomy.

The early development of human haploid parthenotes and androgenotes in comparison with correctly fertilized eggs (biparentals) showed more kinetic differences according to parental composition than haploidy.

Higher Cited2 level in human cumulus cells is associated with decreasing embryo quality and pregnancy outcome in IVF patients, which may be attributed to apoptosis and abnormal gluconeogenesis in cumulus cells.

Measuring the plasma concentrations of kisspeptin, this study reveals groundbreaking evidence suggesting that kisspeptin and luteinizing hormone are cosecreted and temporally coupled in healthy women.

Increased risk of cardiovascular disease in parents of polycystic ovary syndrome as evidenced by increased carotid intima media thickness and low brachial artery flow-mediated dilatation as compared with matched controls.

In polycystic ovary syndrome (PCOS), higher PDCD4 expression promotes obesity, insulin resistance, lipid metabolism disorders, and induced granulosa cell apoptosis, which is an independent risk factor for PCOS.

We discuss how total testosterone levels were predicted by sonographic markers of ovarian morphology, not hirsutism scores; and how the predictive value of ovarian morphology for total testosterone differed by menstrual cycle status.

Antiandrogenic treatment appears to have a beneficial effect on working memory in women with polycystic ovary syndrome.

For 37,711 embryos analyzed with 24-chromosome single-nucleotide polymorphism–based preimplantation genetic screening, the number, proportion, and probability of embryos testing as euploid per IVF cycle were stratified by maternal age.

Recommended reporting items, such as confidence intervals and absolute differences, are underused in top infertility journals, which could lead to misleading interpretations.

An episode of intermenstrual bleeding statistically significantly decreases the odds of conception in the current cycle but does not appear to negatively impact a woman’s future reproductive potential.

This study shows an association between lipoprotein(a) concentrations and history of stillbirth and preeclampsia. This well known atherothrombotic marker might represent one of the mechanisms shared by obstetrical and cardiovascular disease.

Members of the Society of Reproductive Endocrinologists and Infertility have a focused practice, sense a change in scope of practice, envision minimal growth, and have very high professional satisfaction.

In addition to financial access influencing who receives a medical evaluation for infertility, demographic and healthy lifestyle characteristics are associated with a medical evaluation for infertility among infertile women.

Estrogen receptor (ER) b is aberrantly overexpressed in ectopic endometriotic tissues. This study demonstrates that ERb regulates the transcription of SGK1, a kinase that promotes apoptotic resistance in endometriosis via FOXO3 inactivation.

A forecasting method was developed to predict first trimester pregnancy outcomes through ultrasound scan on days 27–29 after ET and the follow-up can be planned accordingly.

Small fibroids seem to grow rapidly in the first weeks of pregnancy, with a nonlinear trend, in relation to the similar growth of human chorionic gonadotropin in the same period.

Four circulating miRNAs (miR-320b, miR-146b-5p, miR-221-3p, miR-559) were up-regulated and one miRNA (miR-101-3p) was down-regulaed in unexplained recurrent spontaneous abortion (URSA). These circulating microRNAs may be involved in URSA pathogenesis and provide a promising new diagnostic biomarker for URSA.

Our prospective, cohort study demonstrates that the use of aspirin may be associated with an increased risk of developing subchorionic hematomas in early pregnancies.

Diminished ovarian reserve may be a hidden cause for recurrent miscarriage regardless of maternal age.

A 34-year-old woman conceived through in vitro fertilization using autologous zona-free oocytes after intracytoplasmic sperm injection and embryo transfer of morula and blastocyst, resulting in a term twin live birth.

Low-dose human chorionic gonadotropin can be used to complete follicle maturity after gonadotropin releasing hormone antagonist administration in the late follicular phase of a natural cycle, leading to successful pregnancies in modified natural cycle in vitro fertilization.

We found that the implantation potential is negatively affected by the biopsied cell number in blastocysts with poor trophectoderm morphological score.

This study demonstrates that the usable blastocyst rate is greatest after culture in sequential media in comparison with monophasic; however, no difference exists in timing of blastulation, aneuploidy, or sustained implantation rate.

Slower very early first-trimester human chorionic gonadotropin rise is associated with low birth weight but not gestational age at delivery among singleton in vitro fertilization conceptions.

Frozen embryo transfers performed immediately after fresh in vitro fertilization cycles had clinical pregnancy rates similar to those postponed to a later time. Therefore, deferring frozen embryo transfers may unnecessarily prolong the time to pregnancy.

Human immunodeficiency virus 1 infection in women is associated with poorer assisted reproductive technology (ART) outcomes in a match-paired, case-control study, which indicates no ART delay in cases with HIV-1 controlled infection.

This study aims at examining whether dichorionic twin pregnancies resulting from assisted reproductive technology have a higher risk of adverse obstetric outcomes compared with those conceived naturally by conducting a systematic review and meta-analysis.

Sequencing of the ALKBH5 and FTO genes in patients with male factor infertility identified one genetic variant in the FTO gene to be associated with reduced semen quality and two FTO missense variants.

Human testicular tissue can be preserved for 3 days at 4C in DMEM/F12, without altering tissue morphology, Sertoli cell morphology, number of spermatogonia per area, or number of apoptotic cells.

Sometimes one looks to the past 50 years in the field of reproductive medicine with veneration and recognition of truly amazing scientific progress. Other times, however, one must humbly acknowledge that despite the remarkable innovations over these years, there are still open questions. In the May 1966 issue of Fertility and Sterility, there was an article by C.A. Joel titled, “New etiologic aspects of habitual abortion and infertility, with special reference to the male factor” (1). An article in the January 2016 issue of Fertility and Sterility examined the same idea: the relationship between recurrent pregnancy loss and sperm characteristics (2). Despite the improvements and advances in the field, 50 years later, this relationship has yet to be expounded.

Reflections on “In-bag manual versus uncontained power morcellation for laparoscopic myomectomy: randomized controlled trial” by Venturella et al.

Reflections on “Does polycystic ovarian syndrome affect cognition: a functional MRI study exploring working memory” by Soleman et al.

Reflections on “Misleading reporting and interpretation of results in major infertility journals” by Glujovsky et al.

The suitability of reproductive donors who have received smallpox vaccine is discussed.

All in vitro fertilization programs and clinics should have plans for the protection of fresh and cryopreserved human tissue and continuation of patient care in the event of an emergency or natural disaster.

It is recommended that practitioners defer gamete donors who have confirmed or suspected West Nile virus infections.

The availability of reliable 24 chromosome aneuploidy screening platforms has provided clinicians and scientists with a powerful new diagnostic tool in the embryology laboratory. Class I data demonstrate increased implantation and delivery rates and reduced multiple gestation rates by empowering more effective single ET after preimplantation genetic screening (PGS) is performed on trophectoderm biopsies (1, 2). Sustained implantation rates of 60% or higher are routinely being attained in multiple programs after synchronous transfer of euploid blastocysts—even in women in their early forties.

Reflections on “Outcomes of in vitro fertilization with preimplantation genetic diagnosis: an analysis of the United States Assisted Reproductive Technology Surveillance Data, 2011–2012” by Chang et al.