Progestin stimulated extracellular matrix formation in immortalized human leiomyoma two-dimensional and three-dimensional cultures, and mifepristone inhibited progestin-stimulated extracellular matrix protein components involved in aberrant fibrosis.
Decreased expression of GRIM-19 may play a role in adenomyosis by regulating apoptosis and angiogenesis.
This study demonstrates for the first time that oocytes with normal spindle morphology are more likely to produce euploid embryos compared with oocytes with translucent or no visible meiotic spindles.
Dysregulated leukemia inhibitory factor and its receptor regulated signal transducers and activators of transcription 3 pathway: a possible cause for repeated implantation failure in women with dormant genital tuberculosis
Poor expression of implantation markers and altered leukemia inhibitory factor–signal transducers and activators of transcription 3 (LIF-STAT3) signaling in women with dormant genital tuberculosis is associated with implantation failure. Alterations in LIF-STAT3 signaling in heat shock protein-65-treated human endometrial stromal cells confirms compromised endometrial decidualization.
Epidermal growth factor containing fibulin like extracellular matrix protein 1 EFEMP1 expression and regulation in uterine leiomyoma
Epidermal growth factor–containing fibulin-like extracellular matrix protein 1 gene expression and fibulin- 3 protein expression are significantly down-regulated in leiomyomas versus myometrium in vivo and in vitro. Differences in expression are partially due to differences in methylation status.
Comparative assessment of five serum antimullerian hormone assays for the diagnosis of polycystic ovarian syndrome
The performance of the different commercial antimullerian hormone assays for polycystic ovary syndrome diagnosis is comparable, but different threshold values should be used for automatic and manual assays.
Oral follicle stimulating hormone agonist tested in healthy young women of reproductive age failed to demonstrate effect on follicular development but affected thyroid function
Oral administration of an FSH agonist demonstrated acceptable exposure and was well tolerated. No clear effect was observed on follicular development; higher doses were not tested owing to thyroid function test changes.
Distribution patterns of segmental aneuploidies in human blastocysts identified by next generation sequencing
Next-generation sequencing allows for the detection of pure and mosaic segmental aneuploidies with the same efficiency as array comparative genomic hybridization.
Is the resulting phenotype of an embryo with balanced X autosome translocation obtained by means of preimplantation genetic diagnosis linked to the X inactivation pattern?
In female balanced X-autosome translocation, normal/balanced female embryos obtained after a preimplantation genetic diagnosis procedure and transferred have a potential risk of clinical abnormalities owing to the uncertain outcome of X inactivation.
Western style diet with and without chronic androgen treatment alters the number structure and function of small antral follicles in ovaries of young adult monkeys
Consumption of a Western-style diet by female nonhuman primates with and without mildly elevated testosterone alters small antral follicle morphology, numbers, health, and RNA transcriptome.
Women who conceived with fertility treatments were more likely to stop breast feeding and provide formula to their infants earlier. A higher prevalence of preterm birth does not fully explain these associations.
Hepatitis B surface antigen in oocytes and embryos may not result in vertical transmission to offspring of hepatitis B virus carriers
Children from oocytes and embryos infected with hepatitis B virus (HBV) were not chronically infected after birth; the HBsAg in oocytes and embryos may not result in vertical transmission.
Effect of chronic hypertension on assisted pregnancy outcomes: a population based study in Ontario, Canada
In 807,765 singleton pregnancies in Ontario, Canada, the risk of placental complications was sixfold higher in hypertensive women using assisted reproduction technology compared with normotensive women in unassisted pregnancies.
Potential influence of in utero and early neonatal exposures on the later development of endometriosis
Women with endometriosis, in addition to genetic predisposition, are exposed more frequently to preterm birth during intrauterine life and to formula feeding in early postnatal life.
Our study showed that, in Caucasian women, genetic variants in the PLGF rs2268613 gene influences PLGF plasma levels. Plasma levels of VEGF were elevated in endometriosis patients compared with controls.
Endometriosis related infertility: assisted reproductive technology has no adverse impact on pain and quality of life scores
Assisted reproduction technology has no adverse impact on pain symptoms or quality of life in women with endometriosis of any phenotype as compared with healthy women.
Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients
Excising endometriotic lesions significantly decreased circulating levels of inflammatory cytokines. Levels were also higher than in normal women, dissimilar in eutopic versus ectopic endometrium, and influenced by disease stage.
Cesarean scar pregnancies are challenging to diagnose and treat owing to the heterogenic appearance and treatment possibilities. This systematic review supports an interventional rather than medical approach.
Following declining human chorionic gonadotropin values in pregnancies of unknown location: when is it safe to stop?
A human chorionic gonadotropin decline of >85% in 4 days or >95% in 1 week effectively rules out the presence of an ectopic pregnancy.
Antimüllerian hormone and pregnancy loss from the Effects of Aspirin in Gestation and Reproduction trial
Lower and higher antimullerian hormone levels are not associated with human chorionic gonadotropin- detected or clinical pregnancy loss in unassisted conceptions in women with a history of pregnancy loss.