Progestin stimulated extracellular matrix formation in immortalized human leiomyoma two-dimensional and three-dimensional cultures, and mifepristone inhibited progestin-stimulated extracellular matrix protein components involved in aberrant fibrosis.
Poor expression of implantation markers and altered leukemia inhibitory factor–signal transducers and activators of transcription 3 (LIF-STAT3) signaling in women with dormant genital tuberculosis is associated with implantation failure. Alterations in LIF-STAT3 signaling in heat shock protein-65-treated human endometrial stromal cells confirms compromised endometrial decidualization.
Epidermal growth factor–containing fibulin-like extracellular matrix protein 1 gene expression and fibulin- 3 protein expression are significantly down-regulated in leiomyomas versus myometrium in vivo and in vitro. Differences in expression are partially due to differences in methylation status.
The performance of the different commercial antimullerian hormone assays for polycystic ovary syndrome diagnosis is comparable, but different threshold values should be used for automatic and manual assays.
Oral administration of an FSH agonist demonstrated acceptable exposure and was well tolerated. No clear effect was observed on follicular development; higher doses were not tested owing to thyroid function test changes.
In female balanced X-autosome translocation, normal/balanced female embryos obtained after a preimplantation genetic diagnosis procedure and transferred have a potential risk of clinical abnormalities owing to the uncertain outcome of X inactivation.
Women who conceived with fertility treatments were more likely to stop breast feeding and provide formula to their infants earlier. A higher prevalence of preterm birth does not fully explain these associations.
In 807,765 singleton pregnancies in Ontario, Canada, the risk of placental complications was sixfold higher in hypertensive women using assisted reproduction technology compared with normotensive women in unassisted pregnancies.
Our study showed that, in Caucasian women, genetic variants in the PLGF rs2268613 gene influences PLGF plasma levels. Plasma levels of VEGF were elevated in endometriosis patients compared with controls.
Excising endometriotic lesions significantly decreased circulating levels of inflammatory cytokines. Levels were also higher than in normal women, dissimilar in eutopic versus ectopic endometrium, and influenced by disease stage.
Cesarean scar pregnancies are challenging to diagnose and treat owing to the heterogenic appearance and treatment possibilities. This systematic review supports an interventional rather than medical approach.
Lower and higher antimullerian hormone levels are not associated with human chorionic gonadotropin- detected or clinical pregnancy loss in unassisted conceptions in women with a history of pregnancy loss.
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