Women with large uterine fibroids delivered at an earlier gestational age compared to women with small or no fibroids. Blood loss and rate of blood transfusion were also increased.

Results from previous studies investigating the potential association between surgical menopause due to bilateral oophorectomy and increased mortality are mixed. Bilateral oophorectomy was not associated with increased mortality in the California Teachers Study.

Associations of childbearing history with all-cause and cardiovascular disease (CVD) mortality in postmenopausal women were examined. High gravidity was associated with reduced CVD and non–coronary heart disease CVD mortality, independent of covariates.

Women with malignant disease have a significantly lower oocyte retrieval rate compared with agematched healthy controls; specific malignancy or stage effect on ovarian response to stimulation cannot be assessed.

Measures of ovarian reserve are impaired among cancer survivors compared with unexposed females of similar age. The degree of impairment is dependent on the toxicity of the previous treatment.

The prevalence of NR5A1 mutations in a large cohort of well-phenotyped women with secondary amenorrhea and diagnosed with POI was only 1.4%, which is substantially lower than previously reported.

The examination of 66 in vitro fertilization–conceived children and 69 control children revealed no imprinting abnormalities at H19, KCNQ1OT1, SNRPN, or IGF2. Satellite 2 methylation was normal, and no global changes in methylation were detected.

Few predictors contribute to the variability seen in chemotherapy-related amenorrhea (CRA) among premenopausal women with breast cancer; later age at menarche and smoking increase the odds of CRA.

A comprehensive approach to women with severe Asherman syndrome and amenorrhea is outlined including standardized preoperative, operative, and postoperative care. All women resumed menses, and 50% conceived after treatment.

Polydeoxyribonucleotide administration in experimental varicocele improved testicular angiogenesis. This event might imply an augmented oxygen supply, a subsequent balance of the apoptotic mechanism, and an improvement of spermatogenesis.

The effects of tinzaparin and enoxaparin on decidual cells were evaluated. Tinzaparin induced heparinbinding epidermal growth factor–like growth factor expression and secretion. Both low-molecular-weight heparins prevented tumor necrosis factor (TNF) a–induced apoptosis of decidual cells.

The increased incidence of aberrant meiosis in in vitro–matured human oocytes correlates with persistence of lysine-9 acetylation of histone-3.

Androgens inhibit cell death of decidualizing endometrial stromal cells exposed to oxidative stress signals. Therefore, androgens might play a critical role for decidua processes of embryo implantation and trophoblast invasion.

Ezrin/phospho-ezrin immunoreactivity are present on apical surfaces of the luminal epithelium, around secretory vacuoles and in luminal secretions during the secretory phase. These findings have functional implications for implantation biology.

Immature testicular tissue is more sensitive and shows differential cell-specificity to cryoprotectants. Dimethyl sulfoxide and ethylene glycol are ideal cryoprotectants for immature and adult testicular tissue, respectively.

We have compared open vs. closed systems for mouse and human blastomere vitrification and conclude that the closed system is more efficient in terms of blastomere survival and division.

Lowering of androgens and insulin during pregnancy in mothers with polycystic ovary syndrome reduces anti-Mullerian hormone levels in their daughters, which might reflect a decrease in their follicular mass.

Women with polycystic ovary syndrome have six-fold greater odds of generalized anxiety symptoms compared with control women, suggesting the need to routinely screen for anxiety symptoms.

Treatment with gonadotropin-releasing hormone antagonist improved the clinical, laboratory and ultrasonographic parameters of a pituitary adenoma secreting follicle-stimulating hormone associated with ovarian hyperstimulation which persisted after transsphenoidal surgery.

Patients with polycystic ovary syndrome seem to have thicker femoral cartilage than normal healthy women, but the increase does not correlate with the patients’ clinical parameters.

Antral follicle count and antimullerian hormone rate of decline is similar to histologic oocyte loss.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women and yet remains enigmatic.

The pros and cons of the proposition that PCOS has developmental origins are laid out based on the best available evidence.

While the etiology of PCOS remains a mystery, the evidence in support of the presence of chronic lowgrade inflammation in women with this syndrome is emerging.

Women with PCOS are often obese. There is debate in the literature regarding whether women are obese because of their PCOS status, or if those who become obese are more predisposed to PCOS.

Insulin resistance of variable severity is commonly present in women with PCOS. Arguments and rationale are presented for treating all or only selected women with insulin sensitizing drugs.

Ovarian stimulation before conception is associated with significant elevations in first-trimester testosterone. Further studies are needed to evaluate the effect of early pregnancy testosterone on outcomes.

The third polycystic ovary syndrome (PCOS) consensus report summarizes current knowledge and identifies knowledge gaps regarding various women’s health aspects of PCOS.

Laptop computers connected to Wi-Fi may reduce human sperm quality. Sperm motility and DNA integrity were decreased after 4 hours of exposure to a laptop ex vivo.

Human BRDT is the only BET gene expressed exclusively in testicular germ cells. The BRDT protein is expressed in spermatocytes, round spermatids, elongated spermatids, and ejaculated spermatozoa.

Semen quality and ICSI outcomes may be influenced by food intake and social habits. Therefore, couples seeking assisted reproduction treatment must be advised about the drastic effects of both the male’s and female’s lifestyles on treatment success.

Intracytoplasmic sperm injection is the most effective and safe treatment in case of partial globozoospermia, although spontaneous pregnancies do occur in this population.

We present a proteomic approach to identify a panel of common proteins in fertile men by using the LTQ-Orbitrap mass spectrometer.

Culture media and liquid nitrogen samples from seropositive HIV, HCV, and HBV patients were tested for viral sequences. Our findings indicate the lack of risk of cross-contamination during IVF cycles.

Testing of retinoblastoma tumors provides no proof for epigenetic hypermethylation of the RB1 promoter in retinoblastoma tumors of children conceived by IVF or ICSI.

Although women were more likely to support IVF insurance coverage than men, there was a broad range of opinions addressing age, gender equality, reproductive choice, and economic equity and responsibility.

Almost all Society for Assisted Reproductive Technology member clinics are online, and nearly one-third use social media to connect with patients.

The incidence of first-trimester venous thromboembolism in IVF pregnancies was 0.2%, which was mainly attributed to a 100-fold increased risk in cycles complicated by ovarian hyperstimulation syndrome.

The hCG curves can validly predict outcome in women at risk for ectopic pregnancy; however, misclassification is common. Clinical judgment should trump prediction rules when change in hCG level nears suggested thresholds.