Adverse obstetric outcomes associated with sonographically identified large uterine fibroids

Women with large uterine fibroids delivered at an earlier gestational age compared to women with small or no fibroids. Blood loss and rate of blood transfusion were also increased.

Fertility and Sterility

Jan 01, 2012

January 2012

Bilateral oophorectomy is not associated with increased mortality: the California Teachers Study

Results from previous studies investigating the potential association between surgical menopause due to bilateral oophorectomy and increased mortality are mixed. Bilateral oophorectomy was not associated with increased mortality in the California Teachers Study.

Fertility and Sterility

Jan 01, 2012

January 2012

The association of reproductive history with all-cause and cardiovascular mortality in older women: the Rancho Bernardo Study

Associations of childbearing history with all-cause and cardiovascular disease (CVD) mortality in postmenopausal women were examined. High gravidity was associated with reduced CVD and non–coronary heart disease CVD mortality, independent of covariates.

Fertility and Sterility

Jan 01, 2012

January 2012

Ovarian response to stimulation for fertility preservation in women with malignant disease: a systematic review and meta-analysis

Women with malignant disease have a significantly lower oocyte retrieval rate compared with agematched healthy controls; specific malignancy or stage effect on ovarian response to stimulation cannot be assessed.

Fertility and Sterility

Jan 01, 2012

January 2012

Impact of cancer therapies on ovarian reserve

Measures of ovarian reserve are impaired among cancer survivors compared with unexposed females of similar age. The degree of impairment is dependent on the toxicity of the previous treatment.

Fertility and Sterility

Jan 01, 2012

January 2012

Limited contribution of NR5A1 (SF-1) mutations in women with primary ovarian insufficiency (POI)

The prevalence of NR5A1 mutations in a large cohort of well-phenotyped women with secondary amenorrhea and diagnosed with POI was only 1.4%, which is substantially lower than previously reported.

Fertility and Sterility

Jan 01, 2012

January 2012

Defects in imprinting and genome-wide DNA methylation are not common in the in vitro fertilization population

The examination of 66 in vitro fertilization–conceived children and 69 control children revealed no imprinting abnormalities at H19, KCNQ1OT1, SNRPN, or IGF2. Satellite 2 methylation was normal, and no global changes in methylation were detected.

Fertility and Sterility

Jan 01, 2012

January 2012

Relationship between reproductive history, anthropometrics, lifestyle factors, and the likelihood of persistent chemotherapy-related amenorrhea in women with premenopausal breast cancer

Few predictors contribute to the variability seen in chemotherapy-related amenorrhea (CRA) among premenopausal women with breast cancer; later age at menarche and smoking increase the odds of CRA.

Fertility and Sterility

Jan 01, 2012

January 2012

Comprehensive management of severe Asherman syndrome and amenorrhea

A comprehensive approach to women with severe Asherman syndrome and amenorrhea is outlined including standardized preoperative, operative, and postoperative care. All women resumed menses, and 50% conceived after treatment.

Fertility and Sterility

Jan 01, 2012

January 2012

Polydeoxyribonucleotide administration improves the intra-testicular vascularization in rat experimental varicocele

Polydeoxyribonucleotide administration in experimental varicocele improved testicular angiogenesis. This event might imply an augmented oxygen supply, a subsequent balance of the apoptotic mechanism, and an improvement of spermatogenesis.

Fertility and Sterility

Jan 01, 2012

January 2012

Low-molecular-weight heparins induce decidual heparin-binding epidermal growth factor–like growth factor expression and promote survival of decidual cells undergoing apoptosis

The effects of tinzaparin and enoxaparin on decidual cells were evaluated. Tinzaparin induced heparinbinding epidermal growth factor–like growth factor expression and secretion. Both low-molecular-weight heparins prevented tumor necrosis factor (TNF) a–induced apoptosis of decidual cells.

Fertility and Sterility

Jan 01, 2012

January 2012

Insufficient histone-3 lysine-9 deacetylation in human oocytes matured in vitro is associated with aberrant meiosis

The increased incidence of aberrant meiosis in in vitro–matured human oocytes correlates with persistence of lysine-9 acetylation of histone-3.

Fertility and Sterility

Jan 01, 2012

January 2012

Androgen signaling in decidualizing human endometrial stromal cells enhances resistance to oxidative stress

Androgens inhibit cell death of decidualizing endometrial stromal cells exposed to oxidative stress signals. Therefore, androgens might play a critical role for decidua processes of embryo implantation and trophoblast invasion.

Fertility and Sterility

Jan 01, 2012

January 2012

Expression and activation of the membrane-cytoskeleton protein ezrin during the normal endometrial cycle

Ezrin/phospho-ezrin immunoreactivity are present on apical surfaces of the luminal epithelium, around secretory vacuoles and in luminal secretions during the secretory phase. These findings have functional implications for implantation biology.

Fertility and Sterility

Jan 01, 2012

January 2012

Efficient cryopreservation of testicular tissue: effect of age, sample state, and concentration of cryoprotectant

Immature testicular tissue is more sensitive and shows differential cell-specificity to cryoprotectants. Dimethyl sulfoxide and ethylene glycol are ideal cryoprotectants for immature and adult testicular tissue, respectively.

Fertility and Sterility

Jan 01, 2012

January 2012

Comparison of Cryotip vs. Cryotop for mouse and human blastomere vitrification

We have compared open vs. closed systems for mouse and human blastomere vitrification and conclude that the closed system is more efficient in terms of blastomere survival and division.

Fertility and Sterility

Jan 01, 2012

January 2012

Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters

Lowering of androgens and insulin during pregnancy in mothers with polycystic ovary syndrome reduces anti-Mullerian hormone levels in their daughters, which might reflect a decrease in their follicular mass.

Fertility and Sterility

Jan 01, 2012

January 2012

Increased prevalence of anxiety symptoms in women with polycystic ovary syndrome: systematic review and meta-analysis

Women with polycystic ovary syndrome have six-fold greater odds of generalized anxiety symptoms compared with control women, suggesting the need to routinely screen for anxiety symptoms.

Fertility and Sterility

Jan 01, 2012

January 2012

A pituitary adenoma secreting follicle-stimulating hormone with ovarian hyperstimulation: treatment using a gonadotropin-releasing hormone antagonist

Treatment with gonadotropin-releasing hormone antagonist improved the clinical, laboratory and ultrasonographic parameters of a pituitary adenoma secreting follicle-stimulating hormone associated with ovarian hyperstimulation which persisted after transsphenoidal surgery.

Fertility and Sterility

Jan 01, 2012

January 2012

Ultrasonographic measurement of the femoral cartilage thickness in patients with polycystic ovary syndrome

Patients with polycystic ovary syndrome seem to have thicker femoral cartilage than normal healthy women, but the increase does not correlate with the patients’ clinical parameters.

Fertility and Sterility

Jan 01, 2012

January 2012

A characterization of the relationship of ovarian reserve markers with age

Antral follicle count and antimullerian hormone rate of decline is similar to histologic oocyte loss.

Fertility and Sterility

Jan 01, 2012

January 2012

PCOS: key issues and remaining questions

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women and yet remains enigmatic.

Fertility and Sterility

Jan 01, 2012

January 2012

Does PCOS have developmental origins?

The pros and cons of the proposition that PCOS has developmental origins are laid out based on the best available evidence.

Fertility and Sterility

Jan 01, 2012

January 2012

Is PCOS an inflammatory process?

While the etiology of PCOS remains a mystery, the evidence in support of the presence of chronic lowgrade inflammation in women with this syndrome is emerging.

Fertility and Sterility

Jan 01, 2012

January 2012

Do women with PCOS have a unique predisposition to obesity?

Women with PCOS are often obese. There is debate in the literature regarding whether women are obese because of their PCOS status, or if those who become obese are more predisposed to PCOS.

Fertility and Sterility

Jan 01, 2012

January 2012

Should all women with PCOS be treated for insulin resistance?

Insulin resistance of variable severity is commonly present in women with PCOS. Arguments and rationale are presented for treating all or only selected women with insulin sensitizing drugs.

Fertility and Sterility

Jan 01, 2012

January 2012

Early pregnancy testosterone after ovarian stimulation and pregnancy outcome

Ovarian stimulation before conception is associated with significant elevations in first-trimester testosterone. Further studies are needed to evaluate the effect of early pregnancy testosterone on outcomes.

Fertility and Sterility

Jan 01, 2012

January 2012

Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

The third polycystic ovary syndrome (PCOS) consensus report summarizes current knowledge and identifies knowledge gaps regarding various women’s health aspects of PCOS.

Fertility and Sterility

Jan 01, 2012

January 2012

Use of laptop computers connected to internet through Wi-Fi decreases human sperm motility and increases sperm DNA fragmentation

Laptop computers connected to Wi-Fi may reduce human sperm quality. Sperm motility and DNA integrity were decreased after 4 hours of exposure to a laptop ex vivo.

Fertility and Sterility

Jan 01, 2012

January 2012

Expression of BET genes in testis of men with different spermatogenic impairments

Human BRDT is the only BET gene expressed exclusively in testicular germ cells. The BRDT protein is expressed in spermatocytes, round spermatids, elongated spermatids, and ejaculated spermatozoa.

Fertility and Sterility

Jan 01, 2012

January 2012

Food intake and social habits in male patients and its relationship to intracytoplasmic sperm injection outcomes

Semen quality and ICSI outcomes may be influenced by food intake and social habits. Therefore, couples seeking assisted reproduction treatment must be advised about the drastic effects of both the male’s and female’s lifestyles on treatment success.

Fertility and Sterility

Jan 01, 2012

January 2012

Intracytoplasmic sperm injection in partial globozoospermia

Intracytoplasmic sperm injection is the most effective and safe treatment in case of partial globozoospermia, although spontaneous pregnancies do occur in this population.

Fertility and Sterility

Jan 01, 2012

January 2012

Proteomic approach in the identification of fertility pattern in seminal plasma of fertile men

We present a proteomic approach to identify a panel of common proteins in fertile men by using the LTQ-Orbitrap mass spectrometer.

Fertility and Sterility

Jan 01, 2012

January 2012

Viral screening of spent culture media and liquid nitrogen samples of oocytes and embryos from hepatitis B, hepatitis C, and human immunodeficiency virus chronically infected women undergoing in vitro fertilization cycles

Culture media and liquid nitrogen samples from seropositive HIV, HCV, and HBV patients were tested for viral sequences. Our findings indicate the lack of risk of cross-contamination during IVF cycles.

Fertility and Sterility

Jan 01, 2012

January 2012

IVF and retinoblastoma revisited

Testing of retinoblastoma tumors provides no proof for epigenetic hypermethylation of the RB1 promoter in retinoblastoma tumors of children conceived by IVF or ICSI.

Fertility and Sterility

Jan 01, 2012

January 2012

Expensive but worth it: older parents’ attitudes and opinions about the costs and insurance coverage for in vitro fertilization

Although women were more likely to support IVF insurance coverage than men, there was a broad range of opinions addressing age, gender equality, reproductive choice, and economic equity and responsibility.

Fertility and Sterility

Jan 01, 2012

January 2012

The ART of social networking: how SART member clinics are connecting with patients online

Almost all Society for Assisted Reproductive Technology member clinics are online, and nearly one-third use social media to connect with patients.

Fertility and Sterility

Jan 01, 2012

January 2012

Venous thromboembolism in relation to in vitro fertilization: an approach to determining the incidence and increase in risk in successful cycles

The incidence of first-trimester venous thromboembolism in IVF pregnancies was 0.2%, which was mainly attributed to a 100-fold increased risk in cycles complicated by ovarian hyperstimulation syndrome.

Fertility and Sterility

Jan 01, 2012

January 2012

Performance of human chorionic gonadotropin curves in women at risk for ectopic pregnancy: exceptions to the rules

The hCG curves can validly predict outcome in women at risk for ectopic pregnancy; however, misclassification is common. Clinical judgment should trump prediction rules when change in hCG level nears suggested thresholds.

Fertility and Sterility

Jan 01, 2012