The contribution of superovulation and ovulation induction to the multiple pregnancy epidemic in the U.S. is likely substantial and preventive strategies are needed.

To examine the history of superovulation for ovulation induction, its contributions to reproductive medicine, and its impact on multiple births.

Ovarian stimulation/intrauterine insemination is a significant determinant of the multiple birth epidemic. Redress will require a rethinking of practice patterns. Herein we explore the prospects of prevention, mitigation, and eventual resolution.

We report on how gonadotropins are useful agents for initiating pregnancy in couples with diverse etiologies of infertility; and elimination of conception of multiple gestations is a desired, but as yet not achieved, outcome.

A historical review of gonadotropin therapy is presented with a summary of studies that have examined its use for anovulation, superovulation, and IVF. A view of a future that nearly eliminates its use is proposed.

A 4-hour quantitative real-time polymerase chain reaction method for preimplantation comprehensive 24-chromosome aneuploidy screening was developed and validated. Results demonstrated 97.6% accuracy on cell lines and 98.6% consistency with microarray-based blastocyst diagnoses.

This committee opinion provides physicians with pertinent information that may help to avoid multiple pregnancies and aid in patient counseling regarding their associated risks.

The optimal outcome of in vitro fertilization is the birth of a healthy singleton. Elective single-embryo transfer should be offered to good-prognosis patients. Elective single-embryo transfer utilization should increase with improved awareness and embryology laboratory advances.

STRAW + 10 recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria, recommended application regardless of women’s age, ethnicity, body size or lifestyle characteristics and identified seven research priorities.

Glutathione peroxidase activity in seminal plasma is related to semen quality but has no relation to in vitro fertilization outcome.

Atypical deletion patterns are presented in two oligozoospermic males. The Y chromosome with highly repetitive block sequences in AZFb and AZFc led to deletions by intrachromosomal recombination mechanisms (28w).

The diagnostic method for Y-chromosomal microdeletions in the European Academy of Andrology/European Molecular Genetics Quality Network guidelines has been successfully upgraded to a quadruplex realtime polymerase chain reaction assay that can be readily applied as clinical routine.

This prospective, blinded, nonselection study is the first to determine the negative and positive predictive values of aneuploidy screening for clinical outcome. Results demonstrate that this CCS method can be safely used to discard embryos because they rarely possess significant reproductive potential.

We present a meta-analysis evaluating the safety and efficacy of corifollitropin alfa administration in women undergoing controlled ovarian stimulation in GnRH antagonist down-regulated IVF/ICSI treatment cycles.

Little difference was seen between the total reproductive potential calculations from SART CORS data and from additional data obtained at 3 clinics.

We report on how having embryos frozen is associated with good quality embryos but not having embryos frozen is not a marker of poor embryo quality.

We report on how evaluation and close monitoring of subsequent pregnancies in carriers of a structural chromosome rearrangement ascertained on the basis of recurrent pregnancy loss resulted in a high live birth rate.

Expression of sphingosine-1-phosphate catabolic enzymes and receptors is altered in endometriosis. These modifications enhance the sphingosine-1-phosphate axis, promoting survival and angiogenesis. This may contribute to the establishment and development of endometriosis.

In a large cohort study, women with endometriosis associated infertility were found to have pregnancy and live birth rates similar to women with tubal factor infertility.

The ESC-derived CCL2 enhances the expression of proliferating cell nuclear antigen, survivin, and matrix metalloproteinase-2, decreases tissue inhibitor of metalloproteinase 1/2 expression, and promotes the growth and invasiveness of ESCs in an autocrine manner through the Akt and MAPK/Erk1/2 signal pathway.