Coadministration of visfatin during superovulation improved ovarian expression of visfatin and vascular endothelial growth factor, developmental competency of oocytes, and fertility in aged female mice.
The in vitro treatment of mouse spermatozoa with anti-ACTL7a antibody-containing serum and the active immunization of mice using purified ACTL7a protein resulted in significant reductions in fertility.
Arachidonic acid (AA)–derived prostaglandins are important for reproduction. In this study, AA stimulated the cytosolic phospholipase A2a/cyclooxygenase-2 pathway activation in mouse endometrial stromal cells.
Gene microarray analysis allows comparison of gene expression of adhesion and normal peritoneal tissues. We identified several specific genes with functions relevant to the pathogenesis of postoperative adhesions.
In this prospective cohort study, vigorous PA was associated with reduced fecundability in all women except overweight or obese women. Moderate PA was associated with a small increase in fecundability.
It has been suggested an immunologic mechanism is involved in the development of endometriosis. In a genetic association study, we demonstrated a cumulative effect of FOXP3 and FCRL3 polymorphisms in endometriosis.
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