June 2012

Effect of laparoscopic excision of endometriomas on ovarian reserve: serial changes in the serum antimüllerian hormone levels

Laparoscopic excision of endometriomas decreases serum AMH levels at 6 weeks and 6 months postoperatively, and the level of decrease is more in cysts that are bilateral or 5 cm.

Fertility and Sterility

Jun 01, 2012

June 2012

The risk of gestational diabetes mellitus among Mexican women with a history of infertility and polycystic ovary syndrome

Pregnant Mexican women with a history of infertility and PCOS are at increased risk for developing GDM. This risk should be considered starting early in the second trimester for a timely intervention and to improve the maternal–fetal prognosis.

Fertility and Sterility

Jun 01, 2012

June 2012

Aromatase expression in abdominal omental/visceral and subcutaneous fat depots: a comparison of pregnant and obese women

Aromatase expression and promoter usage differ between omental/visceral and subcutaneous fat. They may serve different endocrine functions and explain why omental fat is linked with the metabolic syndrome and PCOS.

Fertility and Sterility

Jun 01, 2012

June 2012

Smad7 is a transforming growth factor-beta–inducible mediator of apoptosis in granulosa cells

Overexpression of Smad7 induces increased apoptosis, whereas decreased Smad7 expression reduces apoptosis induced by TGF-b in granulosa cells.

Fertility and Sterility

Jun 01, 2012

June 2012

Morphometric-stereological and functional epididymal alterations and a decrease in fertility in rats treated with finasteride and after a 30-day post-treatment recovery period

Finasteride treatment significantly reduces sperm transit time in the epididymis, sperm motility, and fertility parameters. A 30-day post-treatment recovery period was not enough to restore all parameters.

Fertility and Sterility

Jun 01, 2012

June 2012

Exposure to lipid-rich follicular fluid is associated with endoplasmic reticulum stress and impaired oocyte maturation in cumulus-oocyte complexes

Oocytes matured in lipid-rich follicular fluid from obese women exhibit increased oocyte lipid content, induction of endoplasmic reticulum stress genes, and impaired nuclear maturation.

Fertility and Sterility

Jun 01, 2012

June 2012

Retinoic acid suppresses growth of lesions, inhibits peritoneal cytokine secretion, and promotes macrophage differentiation in an immunocompetent mouse model of endometriosis

Retinoic acid inhibition of endometriotic-implant development in mouse model endometriosis may be related to suppression of interleukin-6 and macrophage chemotactic factor-1 production, and promotion of peritoneal macrophage differentiation.

Fertility and Sterility

Jun 01, 2012

June 2012

Suppression of spermatogenesis before grafting increases survival and supports resurgence of spermatogenesis in adult mouse testis

Suppression of spermatogenesis before testis grafting allows spermatogenesis recovery, whereas control tissue degenerates. Testis tissue xenografting could be an important tool for study and preservation of fertility in adult azoospermia.

Fertility and Sterility

Jun 01, 2012

June 2012

Influence of embryo transfer on embryo preimplantation development

A reduction of the ejection speed of the transferred load allows avoidance of a developmental delay and diminishes the injury to the embryos.

Fertility and Sterility

Jun 01, 2012

June 2012

Admissions for early parenting difficulties among women with infants conceived by assisted reproductive technologies: a prospective cohort study

Women who conceive with assisted reproductive technology are at a more than three-fold increased risk of hospital admission for early parenting difficulties compared with women who conceive spontaneously.

Fertility and Sterility

Jun 01, 2012

June 2012

Comparison of warm and cold contrast media for hysterosalpingography: a prospective, randomized study

Two hundred subjects were randomized to undergo hysterosalpingography (HSG) using a 37C or a roomtemperature contrast medium. The warm medium alleviated the pain and decreased vasovagal episodes during HSG.

Fertility and Sterility

Jun 01, 2012

June 2012

Effect of escitalopram on hot flash interference: a randomized, controlled trial

Compared to placebo, escitalopram (10–20 mg/d) for 8 weeks reduced hot flash interference in daily life, a key measure of quality of life. Reduced hot flash interference was correlated with improvements in other hot flash variables.

Fertility and Sterility

Jun 01, 2012

June 2012

Evaluation of the ovarian reserve in women transplanted with frozen and thawed ovarian cortical tissue

The follicle pool in transplanted frozen/thawed ovarian tissue is low compared with normal ovaries, and reduced follicular selection may explain these women's poor reproductive outcomes in assisted reproduction.

Fertility and Sterility

Jun 01, 2012

June 2012

Association between the location of transposed ovary and ovarian function in patients with uterine cervical cancer treated with (postoperative or primary) pelvic radiotherapy

Location of the transposed ovary higher than 1.5 cm above the iliac crest is recommended to avoid ovarian failure after lateral ovarian transposition after primary or adjuvant pelvic radiotherapy.

Fertility and Sterility

Jun 01, 2012

June 2012

Peritoneal cytokines and adhesion formation in endometriosis: an inverse association with vascular endothelial growth factor concentration

The levels of peritoneal fluid vascular endothelial growth factor are inversely associated with development of pelvic adhesions in the course of endometriosis.

Fertility and Sterility

Jun 01, 2012

June 2012

Peak serum estradiol level during controlled ovarian hyperstimulation is associated with increased risk of small for gestational age and preeclampsia in singleton pregnancies after in vitro fertilization

Elevated serum estradiol level on the day of human chorionic gonadotropin administration is associated with adverse obstetrical outcomes.

Fertility and Sterility

Jun 01, 2012

June 2012

Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation

A significant biological pathway, the cell cycle,was identified along with signature protein staining patterns after gene expression of the receptive endometrium was determined via laser microdissected glands and stroma.

Fertility and Sterility

Jun 01, 2012

June 2012

Pretreatment with estrogen does not affect IVF-ICSI cycle outcome compared with no pretreatment in GnRH antagonist protocol: a prospective randomized trial

GnRH antagonist protocols allow friendly IVF procedures for patients but have low convenience to program oocyte retrievals. This study shows that estrogen pretreatment is effective and safe to program antagonist cycles.

Fertility and Sterility

Jun 01, 2012

June 2012

A comparison of live birth rates and cumulative ongoing pregnancy rates between Europe and North America after ovarian stimulation with corifollitropin alfa or recombinant follicle-stimulating hormone

Live birth rates and cumulative pregnancy rates were higher in North America than in Europe after treatment with either corifollitropin alfa or daily recombinant FSH in a double-blind prospective randomized controlled trial.

Fertility and Sterility

Jun 01, 2012

June 2012

Efficacy and safety of human chorionic gonadotropin for follicular phase stimulation in assisted reproduction: a systematic review and meta-analysis

The administration of human chorionic gonadotropin in the early and late follicular phase in controlled ovarian stimulation shows results similar to the conventional regimens, with the advantage of decreasing the doses of follicle-stimulating hormone.

Fertility and Sterility

Jun 01, 2012

June 2012

Perinatal and neonatal outcomes of 494 babies delivered from 972 vitrified embryo transfers

Compared with fresh embryo transfers, vitrified day 3 embryo transfer shows no significant differences in obstetrical and neonatal outcomes. Vitrification is a safe method for the cryopreservation of human day 3 embryos.

Fertility and Sterility

Jun 01, 2012

June 2012

Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis

Children conceived by IVF and/or ICSI are at significantly increased risk for birth defects, and there is no risk difference between IVF children and ICSI children.

Fertility and Sterility

Jun 01, 2012

June 2012

Effect of ovarian stimulation and oocyte retrieval on reproductive outcome in oocyte donors

A cross-sectional survey of 194 previous oocyte donors performed by a standardized telephone questionnaire shows that oocyte donation does not affect donors' short-term reproductive health.

Fertility and Sterility

Jun 01, 2012

June 2012

Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10,000 cycles

Elevated serum P levels are associated with reduced ongoing pregnancy rates regardless of different ovarian responses. Increased P threshold concentration is associated with better ovarian responses.

Fertility and Sterility

Jun 01, 2012

June 2012

Dual trigger of oocyte maturation with gonadotropin-releasing hormone agonist and low-dose human chorionic gonadotropin to optimize live birth rates in high responders

Dual trigger with GnRH agonist and low-dose hCG in high responders with peak E2 levels

Fertility and Sterility

Jun 01, 2012

June 2012

Recording and sorting live human sperm undergoing acrosome reaction

Fluorescent Pisum sativum agglutinin rapidly labels and stabilizes the acrosomal matrix when exocytic fusion pores open in live human sperm, as assessed by confocal microscopy, electron microscopy, and flow cytometry.

Fertility and Sterility

Jun 01, 2012

June 2012

Recommendations for practices utilizing gestational carriers: an ASRM Practice Committee guideline

This document provides the latest recommendations for the use of a gestational carrier, including indications for this technique and the evaluation of carriers and intended parents.

Fertility and Sterility

Jun 01, 2012

June 2012

Can we skip weekends in GnRH antagonist cycles without compromising the final outcome?

The author discusses the challenges in programming GnRH antagonist cycles.

Fertility and Sterility

Jun 01, 2012

June 2012

Hairless or fertile? Finasteride leads to epididymal changes and infertility in rats

Based on published studies, especially animal, the author discusses the evidence for infertile men to consider stopping the use of finasteride.

Fertility and Sterility

Jun 01, 2012

June 2012

The role of the peritoneal cavity in adhesion formation

The authors discuss the risks and prevention of peritoneal adhesions, and the relationship between adhesions and peritoneal fluid to endometriosis found in the literature.

Fertility and Sterility

Jun 01, 2012

June 2012

Adverse perinatal outcome and in vitro fertilization singleton pregnancies: what lies beneath? Further evidence to support an underlying role of the modifiable hormonal milieu in in vitro fertilization stimulation

The author discusses the need to identify methods to minimize risk in IVF conceptions.

Fertility and Sterility

Jun 01, 2012

June 2012

Running interference

The author discusses recent findings on hot flash severity, frequency, and interference by treatment.

Fertility and Sterility

Jun 01, 2012

June 2012

Development and validation of a three-dimensional in vitro model for uterine leiomyoma and patient-matched myometrium

Immortalized leiomyoma and myometrial cells grown in a three-dimensional format maintain the molecular phenotype of the progenitor tissues and create extracellular matrix.

Fertility and Sterility

Jun 01, 2012

June 2012

Full in vitro fertilization laboratory mechanization: toward robotic assisted reproduction?

Technologies related to automation, such as nonsubjective sperm selection, oocyte fertilization, and embryo culture and monitoring, are available, and this means that sample preparation, chemical or biologic reactions, and data collection could be integrated.

Fertility and Sterility

Jun 01, 2012

June 2012

Uterus transplantation: animal research and human possibilities

We describe uterus transplantation research conducted in the animal model and explore its introduction in the human model.

Fertility and Sterility

Jun 01, 2012

June 2012

Ovarian tissue and follicle transplantation as an option for fertility preservation

This review summarizes state-of-the-art of ovarian transplantation and cryopreservation, and the limits and future prospects of these new techniques.

Fertility and Sterility

Jun 01, 2012

June 2012

Germline development from human pluripotent stem cells toward disease modeling of infertility

We summarize the recent advances in the human germline development from pluripotent stem cells and discuss the proposed strategies to develop disease models of infertility using human ESC/iPSC.

Fertility and Sterility

Jun 01, 2012

June 2012

Extreme infertility

New germ cells and new organs open new areas in the approach to treating infertility.

Fertility and Sterility

Jun 01, 2012