Gene networks that regulate prostaglandin and cortisol synthesis are altered in endometriosis, and the proinflammatory milieu of an endometriotic lesion perturbs cortisol synthesis and action.
Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction
Among women undergoing ART, overweight and obesity were related to lower live birth rates. Short-term weight loss was related to higher MII yield but unrelated to clinical outcomes.
Patients with a BMI over 30 have up to 68% lower odds of having a live birth following their first ART cycle.
Twin gestations after fertility treatments are associated significantly with older age, higher prematurity rate, cesarean delivery, and more obstetric complications when compared with those conceived spontaneously.
Management of a cervical heterotopic pregnancy presenting with first-trimester bleeding: case report and review of the literature
We present a case of cervical heterotopic pregnancy that was managed successfully, and we review the existing literature on this topic.
Role of routine monitoring of Liver and Renal Function during treatment of ectopic pregnancies with single-dose Methotrexate protocol
Routine measurement of serum aspartate aminotransferase and creatinine levels may not be necessary before instituting a single-dose methotrexate protocol for the treatment of ectopic pregnancy.
This study demonstrated zona pellucida thickness is not influenced by women's age or hormonal levels and is not a good predictive indicator for IVF clinical outcomes.
In vitro fertilization patients have inherently different risks of multiple birth, even when DET is specified, and this personalized risk can be reliably predicted.
Among couples previously treated by IVF, one in five has a live birth following a spontaneous pregnancy. This should give hope to unsuccessfully treated couples, especially young couples with unexplained infertility.
The Association between Fertility Clinic Performance and Cycle Volume: Implications for Public Reporting of Provider Performance Data
This retrospective longitudinal study of U.S. assisted reproductive technology clinics found no association between clinic success rates and cycle volume despite public reporting and patient utilization of clinic performance data.
Blastocyst intrafallopian transfer is a feasible option in cases of repeated difficult ETs, regardless of whether the patient shows cervical adhesions or any type of genital malformations.
Changes in the hormonal profile and seminal parameters with the use of aromatase inhibitors in the management of infertile men with low testosterone to estradiol ratios
Therapy with 2.5 mg letrozole or 1 mg anastrazole daily, in cases of infertile men with low T/E2 ratios, leads to a significant increase of T/E2 ratio, ejaculate volume, sperm motility, and total motile sperm count.
Screening for partial AZFa microdeletions in the Y chromosome of infertile men – Is it of clinical relevance?
Assessing complete AZFa deletion is important in azoospermic men, but routine assessment of either USP9Y or DDX3Y microdeletions is unjustified, owing to their rarity and inconsistent impact on spermatogenesis.
The ethical considerations of providing fertility treatment to patients when the prognosis is very poor or futile are discussed.
Recommendations for development of an emergency plan for in vitro fertilization programs: a committee opinion
All IVF programs and clinics should have plans for protection of fresh and cryopreserved human tissue and continuation of patient care in the event of an emergency or natural disaster.
A discussion is presented about the suitability of donors who have received the smallpox vaccine.
Inflammatory events are involved in the pathogenesis of endometriosis and preterm birth, and a clinical correlation is suggested.
Endometriosis increases the risk of several pregnancy complications; some are caused by ectopic lesions, whereas others may reflect the impact of an adverse uterine environment on placenta formation.
We discuss how current therapies for dysfunctional reproductive tissues are often not adequate, and the study of the tissue engineering strategies designed to repair or replace damaged organs.