July 2012

All the papers from the July 2012 issue of Fertility and Sterility.

2-methoxyestradiol causes functional repression of transforming growth factor-β3 signaling by ameliorating Smad and non-Smad signaling pathways in immortalized uterine fibroid cells

The profibrotic response of transforming growth factor (TGF) b3 in fibroid cells is mediated by Smad-dependent and Smad-independent PI3K/Akt/mTOR pathways. 2-Methoxyestradiol inhibits TGF-b3 profibrotic effects in fibroid cells by ameliorating both Smad-dependent and Smad-independent signaling pathways.