This study evaluated the effect of short-term postoperative sunitinib administration on reproductive function after surgical uterine abrasion in a rabbit model, and found that it ameliorated adhesion-induced reproductive aberrations.
Phosphodiesterase 9A (PDE9A), a cyclic guanosine monophosphate–specific phosphodiesterase detectable in germinal vesicle oocytes, likely promotes maturation events upstream of PDE3A, making it a candidate target for nonhormonal contraception.
Adiponectin receptors, expressed in mouse and human granulosa cells and cumulus cell-oocyte complexes, mediate differential gene expression in mouse cumulus cells versus granulosa cells and enhance oocyte maturation/embryo development.
In vitro fertilization failure predicts psychological distress, but not the reverse. Psychological interventions should focus on helping patients cope with treatment as opposed to specifically increasing the chance of pregnancy.
Self-reported psychosocial stress, anxiety, and depression were not associated with fecundity. Any adverse effect of stress or psychological disturbance does not appear to be detectable via the questionnaires administered.
A qualitative descriptive study of the experiences of infertile women in Jordan. Four key themes emerged: the adversity of incomplete being, the social adversity of being infertile, the adversity of another wife, and the adversity of changes in the marital relationship. These adversities need to be conceptualized within a framework that can be used to empower and counsel infertile women.
Gene expression of human cumulus cells is a promising tool to predict oocyte quality in intracytoplasmic sperm injection patients. This retrospective study pinpointed CAMK1D and EFNB2 as strong genes to predict pregnancy outcome.
Investigating contributory factors to infertility in a man with two phospholipase C zeta (PLCz) mutations found loss-of-activity mutations in PLCz potentially resulting in a slower rate of mutant protein transcription.
Immortalized ectopic endometriotic stromal cells produced complement C3 and pentraxin-3 as major secretory proteins in comparison to eutopic counterparts, and revealed different regulation in iron metabolism.
The different expression of PI-PLC enzymes in the endometrium and endometriosis tissue suggests the hypothesis that PI-PLC enzymes, main effectors in PI signaling, might be involved in the pathogenesis of endometriosis.
Race/ethnicity is likely related to ART outcomes; however, race/ethnicity is indeterminate in >35% of SART-reported cycles. Racial/ethnic influences on ART outcomes would be better understood if race/ethnicity was universally reported.
Mucin-1 expression is lower in peri-implantation endometrium of women with recurrent pregnancy loss than in controls, but pinopode morphology and coverage, and leukemia inhibitory factor and integrin-b3 expression are similar.