High singleton live birth rate confirmed after ovulation induction in women with anovulatory polycystic ovary syndrome: validation of a prediction model for clinical practice

Classical ovulation induction is an effective therapy for women with polycystic ovary syndrome. Women with a poor treatment prognosis can be identified according to age, duration of infertility, and body mass index.

Fertility and Sterility

Sep 01, 2012

September 2012

Effect of slow freeze versus vitrification on the oocyte: an animal model

This study adds to the increasing body of evidence that cryopreservation protocols vary in their impact upon the oocyte.

Fertility and Sterility

Sep 01, 2012

September 2012

Identification and Characterization of the Human Leiomyoma Side Population as Putative Tumor-Initiating Cells

The side population method was used to isolate and identify putative tumor-initiating leiomyoma stem cells as demonstrated by their ability to differentiate in vitro and reconstruct leiomyoma tissue in vivo.

Fertility and Sterility

Sep 01, 2012

September 2012

Population-based study of attitudes toward posthumous reproduction

Almost half of the general public supports posthumous reproduction. Age, education, income, political party, currently attempting conception, supporting in vitro fertilization, and organ donation were all associated with support.

Fertility and Sterility

Sep 01, 2012

September 2012

Roles of microRNA-21 and programmed cell death 4 in the pathogenesis of human uterine leiomyomas

PDCD-4 is unexpectedly elevated in leiomyomas, but normal myometrium does not express the protein; the expected inverse correlation of microRNA-21 and its target PDCD-4 is absent in fibroids.

Fertility and Sterility

Sep 01, 2012

September 2012

Live birth after transplantation of frozen-thawed ovarian tissue after bilateral oophorectomy for benign disease

Ovarian function was restored and pregnancy achieved in a woman who had previously undergone bilateral oophorectomy for benign disease and in whom frozen-thawed ovarian cortex was subsequently autotransplanted.

Fertility and Sterility

Sep 01, 2012

September 2012

Proteomic identification of neurotrophins in the eutopic endometrium of women with endometriosis

Proteomic analysis of neurotrophins within the functional layer of the endometrium identified two factors that are expressed differentially in the eutopic endometrium of women with endometriosis compared to controls.

Fertility and Sterility

Sep 01, 2012

September 2012

Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case-control studies

In this systematic review and meta-analysis of case-control studies, we found a small but statistically significant effect of early menarche on endometriosis risk when potential confounders are adequately controlled for.

Fertility and Sterility

Sep 01, 2012

September 2012

Developing symptom-based predictive models of endometriosis as a clinical screening tool: results from a multicenter study

Symptom-based models predict any-stage endometriosis poorly and stage III and IV disease accurately. A tool based on such models can help prioritise women for surgical investigation.

Fertility and Sterility

Sep 01, 2012

September 2012

Duarte galactose-1-phosphate uridyl transferase genotypes are not associated with ovarian cancer risk

This study suggests that Duarte1 and Duarte2 genotypes do not appear to play a role in the association from galactose intake, possible ovarian dysfunction, and the link with ovarian cancer.

Fertility and Sterility

Sep 01, 2012

September 2012

Preterm delivery and low birth weight in singleton pregnancies conceived by women with and without a history of infertility

Nulliparous women and women with a history of infertility who conceive a singleton after infertility treatment may be at increased risk for having a low-birthweight infant.

Fertility and Sterility

Sep 01, 2012

September 2012

Idiopathic Recurrent Miscarriage is Caused Mostly by Aneuploid Embryos

Current preimplantation screening results with array comparative genomic hybridization indicatea significant decrease in the miscarriage rate of idiopathic recurrent pregnancy loss patients. Furthermore, this confirms that idiopathic recurrent miscarriage is mostly caused by chromosomal abnormalities in embryos.

Fertility and Sterility

Sep 01, 2012

September 2012

Can in vitro fertilization cycles be salvaged by repeat administration of intramuscular human chorionic gonadotropin the day after failed injection?

This study investigated the incidence of failed hCG administration as evidenced by negative serum β-hCG after initial trigger injection, and the ability to salvage such cycles through repeat administration of hCG before retrieval.

Fertility and Sterility

Sep 01, 2012

September 2012

Premature progesterone rise negatively correlated with live birth rate in IVF cycles with GnRH agonist: an analysis of 2,566 cycles

This retrospective analysis showed that premature progesterone rise (PPR) impaired in vitro fertilization outcomes in fresh embryo transfer, whereas no negative impact on frozen embryo transfer was observed, implying deleterious effects of PPR on endometrial receptivity.

Fertility and Sterility

Sep 01, 2012

September 2012

Prediction of in vitro fertilization outcome at different antral follicle count thresholds in a prospective cohort of 1,012 women

While AFC and age are predictive of live birth following IVF treatment, AFC demonstrates a stronger positive correlation. This study illustrates post-test probabilities of live birth at individual AFC thresholds.

Fertility and Sterility

Sep 01, 2012

September 2012

An embryo cleavage pattern based on the relative blastomere size as a function of cell number for predicting implantation outcome

The embryo's cleavage pattern provides valuable supplementary information to the standard evaluation for selecting embryos by cleavage rate and fragmentation, enhancing the likelihood for successful implantation.

Fertility and Sterility

Sep 01, 2012

September 2012

Oocyte vitrification does not increase the risk of embryonic aneuploidy or diminish the implantation potential of blastocysts created after intracytoplasmic sperm injection: a novel, paired randomized controlled trial using DNA fingerprinting

Using a novel, paired study design, this RCT demonstrates that blastocysts derived from previously vitrified oocytes are not at an increased risk of aneuploidy and have equivalent reproductive potential.

Fertility and Sterility

Sep 01, 2012

September 2012

Acute Effects of Blood transfusion on Pituitary Gonadal Axis and Sperm Parameters in Adolescents and Young Menwith Thalassemia Major: A Pilot Study

This study suggests that in thalassemic men, blood transfusion is associated with significant acute enhancement of sperm parameters and increased concentrations of serum T, LH, FSH, and IGF-1.

Fertility and Sterility

Sep 01, 2012

September 2012

Comparison of two ready-to-use systems designed for sperm-hyaluronic acid binding selection before intracytoplasmic sperm injection: PICSI versus Sperm Slow: a prospective, randomized trial

PICSI and Sperm Slow allow comparable clinical efficiency in selecting HA-bound spermatozoa.

Fertility and Sterility

Sep 01, 2012

September 2012

A comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury

This study was intended to compare the effects of NAC and EP on experimental testicular I/R injury. The NAC therapy may be regarded as a relatively more effective treatment than EP.

Fertility and Sterility

Sep 01, 2012

September 2012

Autocrine regulation of human sperm motility by the met-enkephalin opioid peptide

A novel role of the opioid system in the regulation of sperm function is demonstrated that shows that both exogenous and endogenous met-enkephalin can modulate sperm motility.

Fertility and Sterility

Sep 01, 2012

September 2012

Ten years' experience with an external quality control program for semen analysis

Voluntary participation in this external quality control program improved overall performance of semen analysis. Surprisingly,

Fertility and Sterility

Sep 01, 2012

September 2012

Recognizing the Limitations of a Meta-Analysis

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Fertility and Sterility

Sep 01, 2012

September 2012

Can we finally move away from the surgical diagnosis of endometriosis?

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Fertility and Sterility

Sep 01, 2012

September 2012

Thawed human ovarian tissue does have fertility potential

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Fertility and Sterility

Sep 01, 2012

September 2012

Commentary on 10 years' experience with an external quality control program for semen analysis

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Fertility and Sterility

Sep 01, 2012

September 2012

New Science Will Move Fibroid Therapies Into the 21st Century

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Fertility and Sterility

Sep 01, 2012

September 2012

Evidence-Based Reproductive Risk Epidemiology: the importance of Multi-disciplinary and Multi-professional Methodological Collaboration

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Fertility and Sterility

Sep 01, 2012

September 2012

Does ovulation induction with follicle-stimulating hormone still have a future in polycystic ovary syndrome?

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Fertility and Sterility

Sep 01, 2012

September 2012

Position statement on West Nile virus: a committee opinion

It is recommended that practitioners defer gamete donors who have confirmed or suspected West Nile virus infections.

Fertility and Sterility

Sep 01, 2012

September 2012

Endometriosis and infertility: a committee opinion

The purpose of this document is to summarize the current therapies for endometriosis.

Fertility and Sterility

Sep 01, 2012

September 2012

In Vitro Production of Haploid Cells after Coculture of CD49f+ with Sertoli Cells from testicular sperm extraction in Nonobstructive Azoospermic Patients

In vitro co-culture of CD49f+ with Sertoli cells from TESE, obtained in azoospermic patients, promotes meiosis progression as demonstrated by SCP3 and CREST staining and generation of haploid cells.

Fertility and Sterility

Sep 01, 2012

September 2012

The pathophysiology of uterine adenomyosis: An update

The article outlines current understanding of the etiology of adenomyosis and the role of the myometrium, and outlines how MRI and transvaginal ultrasound have enhanced our understanding of the disease.

Fertility and Sterility

Sep 01, 2012

September 2012

Deep endometriosis: Definition, diagnosis and treatment

Deep endometriosis remains a subject of debate. A comprehensive overview of the definition, pathophysiology, prevalence, classification, diagnosis, and treatment was therefore attempted.

Fertility and Sterility

Sep 01, 2012

September 2012

Surgical treatment of ovarian endometriomas: state of the art?

Surgery has a fundamental role to play in the treatment of endometriomas. Considerable surgical experience is required, however, to minimize ovarian damage.

Fertility and Sterility

Sep 01, 2012

September 2012

Pharmacologic therapies in endometriosis: a systematic review

Many pharmacological groups were tested in in vitro/animal models of endometriosis and a smaller number of them were tried in humans. A few alternatives for the treatment of this disease can now be considered.

Fertility and Sterility

Sep 01, 2012

September 2012

Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology

NF-kB activation upregulates 18 inflammation and cell proliferation and inhibits apoptosis of 19 endometriotic cells. Iron overload-mediated NF-kB activation is postulated as a mechanism 20 favoring endometriosis development.

Fertility and Sterility

Sep 01, 2012

September 2012

Pathogenesis and Pathophysiology of Endometriosis

Endometriosis is an inflammatory, estrogen-dependent condition associated with pelvic pain and infertility. This work reviews the disease process from theories regarding origin to the molecular basis for disease sequelae.

Fertility and Sterility

Sep 01, 2012

September 2012

Endometriosis: enigmatic in the pathogenesis and controversial in its therapy

Endometriosis prevalence is as high as 35%-50% in women experiencing pain or infertility. This "Views and Reviews" is devoted to the pathogenesis and treatment of this enigmatic disease.

Fertility and Sterility

Sep 01, 2012